Subarea 2: Regeneration and Homeostasis of Organs in Aging
The main goal of Subarea 2 is to identify cellular and molecular pathways used to ensure effective organ maintenance and repair, and to unravel the mechanisms of their deterioration during aging. While stem cells are important for organ homeostasis, this Subarea does not per se directly addresses stem cell aging but rather focusses on the following focus areas:
- Drifts in developmental pathways limiting organ maintenance in aging,
- Immune aging and inflammation, and
- Systemic and micro-milieu regulators of organ maintenance, regeneration, and disease development.
Research focus of Subarea 2
Organ maintenance is regulated by local and systemic factors, which are subject to aging-associated changes. Research of Subarea 2 focuses on the following research areas: a) Genetic and epigenetic modulation of developmental pathways has been shown to contribute to progressive aging and disease. It is critical to delineate mechanisms and consequences of aging-associated drifts to better understand organ maintenance during aging. b) Immunoaging and chronic inflammation elicits negative effects through reduced immune surveillance and aberrant organ repair and maintenance; all of which contributes to the evolution of organ pathologies and diseases during organismal aging. c) Furthermore, aging-associated alterations in systemic and extracellular factors derived from metabolic changes, microbiota alterations, chronic inflammation, senescent, or damaged cells might impinge on disease development and tumor initiation.
Publications
(since 2016)
2016
- Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation.
Liu P, Baumgart M, Groth M, Wittmann J, Jäck HM, Platzer M, Tuckermann* JP, Baschant* U
Sci Rep 2016, 6, 32112 * equal contribution - Different promoter affinities account for specificity in MYC-dependent gene regulation.
Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E
Elife 2016, 5. pii: e15161, doi: 10.7554/eLife.15161. - Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility.
Parra* LM, Hartmann* M, Schubach S, Ma J, Herrlich** P, Herrlich** A
Sci Rep 2016, 6, 37464 * equal contribution, ** co-senior authors - Ezrin functions in brain development and disease
Riecken LB
Dissertation 2016, Jena, Germany - CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.
Riecken LB, Zoch A, Wiehl U, Reichert S, Scholl I, Cui Y, Ziemer M, Anderegg U, Hagel C, Morrison H
Oncotarget 2016, 7(48), 78242-54 - Function of the tumour suppressor protein merlin in neurons of the central nervous system
Rübsam J
Dissertation 2016, Jena, Germany - The importance of nerve microenvironment for schwannoma development.
Schulz A, Büttner R, Hagel C, Baader SL, Kluwe L, Salamon J, Mautner VF, Mindos T, Parkinson DB, Gehlhausen JR, Clapp DW, Morrison H
Acta Neuropathol 2016, 132(2), 289-307 - Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration.
Schulz A, Büttner R, Toledo A, Baader SL, von Maltzahn J, Irintchev A, Bauer R, Morrison H
PLoS One 2016, 11(7), e0159718 - BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.
Song L, Wörmann S, Ai J, Neuhöfer P, Lesina M, Diakopoulos KN, Ruess D, Treiber M, Witt H, Bassermann F, Halangk W, Steiner JM, Esposito I, Rosendahl J, Schmid RM, Riemann M, Algül H
Gastroenterology 2016, 150(2), 499-512 - Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita** Y, Rudolph** KL
J Exp Med 2016, 213(4), 535-53 ** co-corresponding authors
