Marz Associated Research Group

Non-coding RNAs in Aging:
The Regulation of Aging

The group of Manja Marz is associated to the FLI as a cooperation group between the Friedrich Schiller University (FSU) Jena and the FLI - located at the FSU. It deals with the regulation of aging.

A vaste amount of the known vertebrate genes are transcribed as non-coding RNAs (ncRNAs), small molecules playing an important role in the regulation of all kinds of biological pathways. Micro-RNAs
(miRNAs) are a well-known example of such small genetic regulators. Currently, we are aware of around 2400 families of ncRNAs, whose functions are barely known:

  • Which kind of ncRNAs are involved in the processes of aging?
  • What are their exact functions and how big is their influence on different stages of aging? 
  • What is the correlation of ncRNAs and age-dependent diseases, such as neurodegenerative diseases?

The Marz group tries to tackle these questions in an interdisciplinary way by combining state-of-the-art High Throughput Bioinformatics with modern wetlab approaches. The group has an excellent expertise in the in-depth analysis of RNA-Seq data, in silico ncRNA identification and characterization, as well as virus-bioinformatics. Additionally, the group investigates RNA:DNA triplex and G-quadruplex formations, representing a new level of genomic regulation by controlling chromatin organization.

Manja Marz is founding and board member of the Aging Research Center (ARC) Jena and Michael Stifel Centre Jena.


Manja Marz
Associated Group Leader