Publications at FLI

2025

• Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics.
  Bhatti G, Sufriyana H, Romero R, Patel T, Tekola-Ayele F, Alsaggaf I, Gomez-Lopez N, Su ECY, Done B, Hoffmann S, van Bömmel A, Wan C, Albrecht J, Novak C, DREAM Placenta Clock Challenge Consortium, Chaiworapongsa T, Sirota M, Aghaeepour N, Stolovitzky G, Bryant DR, Tarca AL
  iScience 2025, 28(8), 113181
  
• Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network.
  Boutelle AM, Mabene AR, Yao D, Xu H, Wang M, Tang YJ, Lopez SS, Sinha S, Demeter J, Cheng R, Benard BA, McCrea EM, Valente LJ, Drainas AP, Fischer M, Majeti R, Petrov DA, Jackson PK, Yang F, Winslow MM, Bassik MC, Attardi LD
  Cell Death Differ 2025 (epub ahead of print)
  
• Rapid brain tumor classification from sparse epigenomic data.
  Brändl B, Steiger M, Kubelt C, Rohrandt C, Zhu Z, Evers M, Wang G, Schuldt B, Afflerbach AK, Wong D, Lum A, Halldorsson S, Djirackor L, Leske H, Magadeeva S, Smičius R, Quedenau C, Schmidt NO, Schüller U, Vik-Mo EO, Proescholdt M, Riemenschneider MJ, Zadeh G, Ammerpohl O, Yip S, Synowitz M, van Bömmel** A, Kretzmer** H, Müller** FJ
  Nat Med 2025, 31(3), 840-8 ** co-corresponding authors
  
• Translational Remodeling of the Synaptic Proteome During Aging.
  Caterino C, Ugolini M, Durso W, Jevdokimenko K, Groth M, Riege K, Görlach M, Fornasiero E, Ori A, Hoffmann S, Cellerino A
  Aging Cell 2025 (epub ahead of print)
  
• p53 reveals principles of chromatin remodeling and enhancer activation.
  Fischer M, Schwarz* R, Riege* K, Förste S, Schwab K, Wiechens E, van Bömmel A, Hoffmann S
  Nucleic Acids Res 2025, 53(11), gkaf465 * equal contribution
  
• Subtyping Burkitt Lymphoma by DNA Methylation.
  Glaser S, Wagener R, Kretzmer H, López C, Baptista MJ, Bens S, Bernhart S, Bhatia K, Borkhardt A, Elgaafary S, Hoffmann S, Hübschmann D, Hummel M, Klapper W, Kolarova J, Kreuz M, Lazzi S, Löffler M, Navarro JT, Neequaye J, Onyango N, Onyuma T, Ott G, Radlwimmer B, Rohde M, Rosenwald A, Rosolowski M, Schlesner M, Szczepanowski M, Tapia G, Wößmann W, Küppers R, Trümper L, Leoncini L, Lichter P, Del Val C, Ammerpohl O, Burkhardt B, Mbulaiteye SM, Siebert R, ICGC MMML‐Seq Consortium MMML Project
  Genes Chromosomes Cancer 2025, 64(4), e70042
  
• The transcriptome of the olm provides insights into its evolution and gene expression.
  Holtze S, Demirtürk D, Ohlenschläger O, Hegele S, Siniuk K, Förste S, Raghavan V, Groth M, Bens M, Hassel N, Martel A, Lukač M, Cizelj I, Fischer M, Liu H, Hildebrandt TB, Hoffmann S, Sahm A
  Sci Rep 2025, 15(1), 28324
  
• DNA damage response regulator ATR licenses PINK1-mediated mitophagy.
  Marx* C, Qing* X, Gong* Y, Kirkpatrick J, Siniuk K, Beznoussenko GV, Kidiyoor GR, Kirtay M, Buder K, Koch P, Westermann M, Bruhn C, Brown EJ, Xu X, Foiani M, Wang ZQ
  Nucleic Acids Res 2025, 53(5), gkaf178 * equal contribution
  
• Signatures of Nonlinear Aging: Molecular Stages of Life: Sudden Changes During Aging as Potential Biomarkers for an Age Classification System.
  Olecka** M, Morrison H, Hoffmann** S
  Bioessays 2025, 47(5), e202400222 ** co-corresponding authors
  
• Protecting cell cycle integrity: enhanced start-codon stringency in mitosis.
  Omrani O, Siniuk K, Fischer M
  Signal Transduct Target Ther 2025, 10(1), 34