Publications at FLI

2025

• DNA damage response regulator ATR licenses PINK1-mediated mitophagy.
  Marx* C, Qing* X, Gong* Y, Kirkpatrick J, Siniuk K, Beznoussenko GV, Kidiyoor GR, Kirtay M, Buder K, Koch P, Westermann M, Bruhn C, Brown EJ, Xu X, Foiani M, Wang ZQ
  Nucleic Acids Res 2025, 53(5), gkaf178 * equal contribution
  
• Signatures of Nonlinear Aging: Molecular Stages of Life: Sudden Changes During Aging as Potential Biomarkers for an Age Classification System.
  Olecka** M, Morrison H, Hoffmann** S
  Bioessays 2025, 47(5), e202400222 ** co-corresponding authors
  
• Protecting cell cycle integrity: enhanced start-codon stringency in mitosis.
  Omrani O, Siniuk K, Fischer M
  Signal Transduct Target Ther 2025, 10(1), 34
  
• An improved epigenetic age estimation with TFMethyl Clock reveals DNA methylation changes during aging in transcription factor binding sites
  Patel T, Schwarz R, Riege K, Varshavsky M, Kestler HA, Kaplan T, Hoffmann** S, van Bömmel** A
  bioRxiv 2025, https://doi.org/10.1101/2025.10. ** co-corresponding authors
  
• Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool.
  Perçin** G, Riege K, Fröbel J, Metz J, Culemann S, Lesche M, Reinhardt S, Höfer T, Hoffmann S, Waskow** C
  Nat Commun 2025, 16(1), 4428 ** co-corresponding authors
  
• Replication stress responses in human lymphocytes change sex-specifically during aging.
  Rall-Scharpf M, Schlotter D, Koch P, Szafranski K, Groth M, Sahm A, Biber S, Castaño BA, Heitmeir B, Zengerling F, Deniz M, Dallmeier D, Braig S, Bonig H, Milyavsky M, Pospiech H, Wiesmüller L
  Nucleic Acids Res 2025, 53(11), gkaf498
  
• The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.
  Richter* A, Mörl H, Thielemann M, Kleemann M, Geißen R, Schwarz R, Albertz C, Koch P, Petzold A, Kroll T, Groth M, Hartmann N, Herpin A, Englert* C
  Nat Commun 2025, 16(1), 540 * corresponding author
  
• Quantifying cardiovascular autonomic aging with machine learning.
  Schumann A, Gupta Y, Geisler M, de la Cruz F, Gerstorf D, Demuth I, Olecka M, Gaser C, Bär KJ
  Am J Physiol Heart Circ Physiol 2025, 329(6), H1471-9
  
• Synergistic potential of CDK4/6 inhibitors and ATRA in non-APL AML.
  Skopek R, Özcan SG, Chmiel P, Morgner S, Schütt J, Ghazvini Zadegan F, Stanko C, Palusińska M, Maślińska-Gromadka K, Sbirkov Y, Stengel S, Fischer M, Brioli A, Zelent A, Szymański Ł, Schenk T
  Br J Haematol 2025, 207(4), 1279-88
  
• UV laser crosslinking uncovers novel DNA-binding pattern of CTCF*
  Stanko C, Gupse Özcan S, Stengel S, Szymański Ł, Steube A, Fischer M, Brioli A, Schenk T
  bioRxiv 2025, https://doi.org/10.1101/2025.05.