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Home>Research>Subarea 2: Regeneration and Homeostasis of Organs in Aging
Research focus of Subarea 2.

Subarea 2: Regeneration and Homeostasis of Organs in Aging

The main goal of Subarea 2 is to identify cellular and molecular pathways used to ensure effective organ maintenance and repair, and to unravel the mechanisms of their deterioration during aging. While stem cells are important for organ homeostasis, this Subarea does not per se directly addresses stem cell aging but rather focusses on the following focus areas:

  • Drifts in developmental pathways limiting organ maintenance in aging,
  • Immune aging and inflammation, and
  • Systemic and micro-milieu regulators of organ maintenance, regeneration, and disease development.

Research focus of Subarea 2

Organ maintenance is regulated by local and systemic factors, which are subject to aging-associated changes. Research of Subarea 2 focuses on the following research areas: a) Genetic and epigenetic modulation of developmental pathways has been shown to contribute to progressive aging and disease. It is critical to delineate mechanisms and consequences of aging-associated drifts to better understand organ maintenance during aging. b) Immunoaging and chronic inflammation elicits negative effects through reduced immune surveillance and aberrant organ repair and maintenance; all of which contributes to the evolution of organ pathologies and diseases during organismal aging. c) Furthermore, aging-associated alterations in systemic and extracellular factors derived from metabolic changes, microbiota alterations, chronic inflammation, senescent, or damaged cells might impinge on disease development and tumor initiation.

Publications

(since 2016)

2023

  • A YIPF5-GOT1A/B complex directs a transcription-independent function of ATF6 in ER export
    Cramer P, Yonemura Y, Behrendt L, Marszalek A, Sannai M, Durso W, Günes C, Szafranski K, Nakamura N, Nasrashvili T, Mayer J, von Eyss** B, Kaether** C
    bioRxiv 2023, 10.1101/2023.12.12.569033 ** co-corresponding authors
  • Turquoise killifish: A natural model of age-dependent brain degeneration.
    de Bakker DEM, Valenzano DR
    Ageing Res Rev 2023, 90, 102019
  • Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease.
    Dellbrügge F, Jesse LD, Medyukhina A, Liu N, Neugebauer S, Freißmuth M, Höppener S, Figge MT, Morrison H, Riecken LB, Press AT
    Heliyon 2023, 9(11), e21009
  • Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins.
    Frasch MG, Yoon BJ, Helbing DL, Snir G, Antonelli MC, Bauer R
    Biology (Basel) 2023, 12(7)
  • Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2 -Mutant Mice.
    Gerardo-Ramírez M, Giam V, Becker D, Groth M, Hartmann N, Morrison H, May-Simera HL, Radsak MP, Marquardt JU, Galle PR, Herrlich P, Straub BK, Hartmann M
    Cells 2023, 12(9), 1257
  • Polyglucosan body density in the aged mouse hippocampus is controlled by a novel modifier locus on chromosome 1.
    Gómez-Pascual* A, Glikman* DM, Ng* HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski C, Kempermann G, Killmar J, Mozhui K, Aebersold R, Williams EG, Williams** RW, Overall RW, Jucker M, de Bakker** DEM
    bioRxiv 2023, 10.1101/2023.11.22.567373 * equal contribution, ** co-corresponding authors
  • Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury
    Helbing DL, Haas F, Cirri E, Rahnis N, Thuy Dung Dau T, Kelmer Sacramento E, Oraha N, Böhm L, Morrison H, Bauer R
    bioRxiv 2023, 10.1101/2023.04.13.536755
  • Proteomic analysis of peripheral nerve myelin during murine aging.
    Helbing DL, Kirkpatrick JM, Reuter M, Bischoff J, Stockdale A, Carlstedt A, Cirri E, Bauer R, Morrison H
    Front Cell Neurosci 2023, 17, 1214003
  • A dysfunctional miR-1-TRPS1-MYOG axis drives ERMS by suppressing terminal myogenic differentiation.
    Hüttner SS, Henze H, Elster D, Koch P, Anderer U, von Eyss B, von Maltzahn J
    Mol Ther 2023, 31(9), 2612-32
  • Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers
    Jessen M, Gertzmann D, Liss F, Zenk F, Bähner L, Schöffler V, Ade CP, von Eyss B, Gaubatz S
    bioRxiv 2023, 10.1101/2023.07.27.550917