Subarea 2: Regeneration and Homeostasis of Organs in Aging
The main goal of Subarea 2 is to identify cellular and molecular pathways used to ensure effective organ maintenance and repair, and to unravel the mechanisms of their deterioration during aging. While stem cells are important for organ homeostasis, this Subarea does not per se directly addresses stem cell aging but rather focusses on the following focus areas:
- Drifts in developmental pathways limiting organ maintenance in aging,
- Immune aging and inflammation, and
- Systemic and micro-milieu regulators of organ maintenance, regeneration, and disease development.
Research focus of Subarea 2
Organ maintenance is regulated by local and systemic factors, which are subject to aging-associated changes. Research of Subarea 2 focuses on the following research areas: a) Genetic and epigenetic modulation of developmental pathways has been shown to contribute to progressive aging and disease. It is critical to delineate mechanisms and consequences of aging-associated drifts to better understand organ maintenance during aging. b) Immunoaging and chronic inflammation elicits negative effects through reduced immune surveillance and aberrant organ repair and maintenance; all of which contributes to the evolution of organ pathologies and diseases during organismal aging. c) Furthermore, aging-associated alterations in systemic and extracellular factors derived from metabolic changes, microbiota alterations, chronic inflammation, senescent, or damaged cells might impinge on disease development and tumor initiation.
Publications
(since 2016)
2023
- Sperm length evolution in relation to body mass is shaped by multiple trade-offs in tetrapods
Koçillari* L, Cattelan*/* S, Rasotto MB, Seno F, Maritan A, Pilastro A
bioRxiv 2023, 10.1101/2023.09.12.557314 * equal contribution, * corresponding author - A noncanonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth
Kurlishchuk* Y, Cindric Vranesic* A, Jessen* M, Kipping A, Kim K, Cramer P, von Eyss B
bioRxiv 2023, 10.1101/2023.08.20.554005 * equal contribution - Proteomic analysis of peripheral nerve myelin during murine aging
Lucas Helbing D, M.Kirkpatrick J, Reuter M, Bischoff J, Stockdale A, Carlstedt A, Cirri E, Bauer R, Morrison H
bioRxiv 2023, 10.1101/2023.04.26.538413 - Analysis of different strains of the turquoise killifish Nothobranchius furzeri identifies transcriptomic signatures associated with heritable lifespan differences
Mazzetto M, Reichwald K, Kelmer Sacramento E, Koch P, Ori A, Groth M, Cellerino A
bioRxiv 2023, 10.1101/2023.11.20.567823 - Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity.
Monzó C, Gkioni L, Beyer A, Valenzano** DR, Grönke** S, Partridge** L
Cell Rep 2023, 42(7), 112722 ** co-corresponding authors - Assessing Age-Related Decline in Anti-Bacterial Immune Responses Using an Ex-vivo Assay in African Turquoise Killifish (Nothobranchius furzeri)
Morabito G, Aleman FDD, Valenzano DR
bioRxiv 2023, 10.1101/2023.11.24.568569 - Spontaneous onset of cellular markers of inflammation and genome instability during aging in the immune niche of the naturally short-lived turquoise killifish (Nothobranchius furzeri)
Morabito G, Dönertas HM, Seidel J, Poursadegh A, Poeschla M, Valenzano DR
bioRxiv 2023 - Sperm production is negatively associated with muscle and sperm telomere length in a species subjected to strong sperm competition.
Morbiato E, Cattelan S, Pilastro A, Grapputo A
Mol Ecol 2023, 32(31), 5812-22 - Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation.
Refisch A, Sen ZD, Klassert TE, Busch A, Besteher B, Danyeli LV, Helbing D, Schulze-Späte U, Stallmach A, Bauer M, Panagiotou G, Jacobsen ID, Slevogt H, Opel N, Walter M
Neuropharmacology 2023, 235, 109568 - Sequencing the Immunoglobulin Heavy-Chain Locus (IgH) in Turquoise Killifish ( Nothobranchius furzeri).
Seidel J, Bradshaw WJ, Valenzano DR
Cold Spring Harb Protoc 2023, 5
