Subarea 2: Regeneration and Homeostasis of Organs in Aging
The main goal of Subarea 2 is to identify cellular and molecular pathways used to ensure effective organ maintenance and repair, and to unravel the mechanisms of their deterioration during aging. While stem cells are important for organ homeostasis, this Subarea does not per se directly addresses stem cell aging but rather focusses on the following focus areas:
- Drifts in developmental pathways limiting organ maintenance in aging,
- Immune aging and inflammation, and
- Systemic and micro-milieu regulators of organ maintenance, regeneration, and disease development.
Research focus of Subarea 2
Organ maintenance is regulated by local and systemic factors, which are subject to aging-associated changes. Research of Subarea 2 focuses on the following research areas: a) Genetic and epigenetic modulation of developmental pathways has been shown to contribute to progressive aging and disease. It is critical to delineate mechanisms and consequences of aging-associated drifts to better understand organ maintenance during aging. b) Immunoaging and chronic inflammation elicits negative effects through reduced immune surveillance and aberrant organ repair and maintenance; all of which contributes to the evolution of organ pathologies and diseases during organismal aging. c) Furthermore, aging-associated alterations in systemic and extracellular factors derived from metabolic changes, microbiota alterations, chronic inflammation, senescent, or damaged cells might impinge on disease development and tumor initiation.
Publications
(since 2016)
2024
- Gut microbiome in atypical depression.
Busch A, Roy S, Helbing DL, Colic L, Opel N, Besteher B, Walter M, Bauer M, Refisch A
J Affect Disord 2024 (epub ahead of print) - Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review.
Helbing* DL, Dommaschk* EM, Danyeli LV, Liepinsh E, Refisch A, Sen ZD, Zvejniece L, Rocktäschel T, Stabenow LK, Schiöth HB, Walter M, Dambrova M, Besteher B
Eur Arch Psychiatry Clin Neurosci 2024 (epub ahead of print) * equal contribution - Denervation alters the secretome of myofibers and thereby affects muscle stem cell lineage progression and functionality.
Henze H, Hüttner SS, Koch P, Schüler SC, Groth M, von Eyss B, von Maltzahn J
NPJ Regen Med 2024, 9(1), 10 - Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.
Jessen* M, Gertzmann* D, Liss* F, Zenk F, Bähner L, Schöffler V, Schulte C, Maric HM, Ade CP, von Eyss** B, Gaubatz** S
Oncogene 2024 (epub ahead of print) * equal contribution, ** co-corresponding authors - Immune aging in annual killifish.
Morabito G, Ryabova A, Valenzano DR
Immun Ageing 2024, 21(1), 18
2023
- Age-related changes in the peripheral nerves and the identification of exosomal biomarkers for neurofibromatosis type 2 and aging
Bischoff J
Dissertation 2023, Jena, Germany - Female reproductive fluid attracts more and better sperm: implications for within-ejaculate cryptic female choice.
Cattelan S, Devigili A, Santacà M, Gasparini C
Biol Lett 2023, 19(6), 20230063 - Noninvasive Ejaculate Collection from the African Turquoise Killifish Nothobranchius furzeri.
Cattelan S, Valenzano DR
Cold Spring Harb Protoc 2023, 5 - Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice.
Chen J, Salveridou E, Liebmann L, Sundaram SM, Doycheva D, Markova B, Hübner CA, Boelen A, Visser WE, Heuer H, Mayerl S
Int J Mol Sci 2023, 24(4), 3452 - A YIPF5-GOT1A/B complex directs a transcription-independent function of ATF6 in ER export
Cramer P, Yonemura Y, Behrendt L, Marszalek A, Sannai M, Durso W, Günes C, Szafranski K, Nakamura N, Nasrashvili T, Mayer J, von Eyss** B, Kaether** C
bioRxiv 2023, 10.1101/2023.12.12.569033 ** co-corresponding authors
