The main goal of Subarea 2 is to identify cellular and molecular pathways used to ensure effective organ maintenance and repair, and to unravel the mechanisms of their deterioration during aging. While stem cells are important for organ homeostasis, this Subarea does not per se directly addresses stem cell aging but rather focusses on the following focus areas:
- Drifts in developmental pathways limiting organ maintenance in aging,
- Immune aging and inflammation, and
- Systemic and micro-milieu regulators of organ maintenance, regeneration, and disease development.
Research focus of Subarea 2
Organ maintenance is regulated by local and systemic factors, which are subject to aging-associated changes. Research of Subarea 2 focuses on the following research areas: a) Genetic and epigenetic modulation of developmental pathways has been shown to contribute to progressive aging and disease. It is critical to delineate mechanisms and consequences of aging-associated drifts to better understand organ maintenance during aging. b) Immunoaging and chronic inflammation elicits negative effects through reduced immune surveillance and aberrant organ repair and maintenance; all of which contributes to the evolution of organ pathologies and diseases during organismal aging. c) Furthermore, aging-associated alterations in systemic and extracellular factors derived from metabolic changes, microbiota alterations, chronic inflammation, senescent, or damaged cells might impinge on disease development and tumor initiation.
- Female reproductive fluid attracts more and better sperm: implications for within-ejaculate cryptic female choice.
Cattelan S, Devigili A, Santacà M, Gasparini C
Biol Lett 2023, 19(6), 20230063
- Noninvasive Ejaculate Collection from the African Turquoise Killifish Nothobranchius furzeri.
Cattelan S, Valenzano DR
Cold Spring Harb Protoc 2023, 5
- Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice.
Chen J, Salveridou E, Liebmann L, Sundaram SM, Doycheva D, Markova B, Hübner CA, Boelen A, Visser WE, Heuer H, Mayerl S
Int J Mol Sci 2023, 24(4), 3452
- Turquoise killifish: A natural model of age-dependent brain degeneration.
de Bakker DEM, Valenzano DR
Ageing Res Rev 2023 (epub ahead of print)
- Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins.
Frasch MG, Yoon BJ, Helbing DL, Snir G, Antonelli MC, Bauer R
Biology (Basel) 2023, 12(7)
- Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2 -Mutant Mice.
Gerardo-Ramírez M, Giam V, Becker D, Groth M, Hartmann N, Morrison H, May-Simera HL, Radsak MP, Marquardt JU, Galle PR, Herrlich P, Straub BK, Hartmann M
Cells 2023, 12(9), 1257
- Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury
Helbing DL, Haas F, Cirri E, Rahnis N, Thuy Dung Dau T, Kelmer Sacramento E, Oraha N, Böhm L, Morrison H, Bauer R
bioRxiv 2023, 10.1101/2023.04.13.536755
- A dysfunctional miR-1-TRPS1-MYOG axis drives ERMS by suppressing terminal myogenic differentiation.
Hüttner SS, Henze H, Elster D, Koch P, Anderer U, von Eyss B, von Maltzahn J
Mol Ther 2023 (epub ahead of print)
- Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers
Jessen M, Gertzmann D, Liss F, Zenk F, Bähner L, Schöffler V, Ade CP, von Eyss B, Gaubatz S
bioRxiv 2023, 10.1101/2023.07.27.550917
- Sperm length evolution in relation to body mass is shaped by multiple trade-offs in tetrapods
Koçillari* L, Cattelan*/* S, Rasotto MB, Seno F, Maritan A, Pilastro A
bioRxiv 2023, 10.1101/2023.09.12.557314 * equal contribution, * corresponding author