The main goal of Subarea 2 is to identify cellular and molecular pathways used to ensure effective organ maintenance and repair, and to unravel the mechanisms of their deterioration during aging. While stem cells are important for organ homeostasis, this Subarea does not per se directly addresses stem cell aging but rather focusses on the following focus areas:
- Drifts in developmental pathways limiting organ maintenance in aging,
- Immune aging and inflammation, and
- Systemic and micro-milieu regulators of organ maintenance, regeneration, and disease development.
Research focus of Subarea 2
Organ maintenance is regulated by local and systemic factors, which are subject to aging-associated changes. Research of Subarea 2 focuses on the following research areas: a) Genetic and epigenetic modulation of developmental pathways has been shown to contribute to progressive aging and disease. It is critical to delineate mechanisms and consequences of aging-associated drifts to better understand organ maintenance during aging. b) Immunoaging and chronic inflammation elicits negative effects through reduced immune surveillance and aberrant organ repair and maintenance; all of which contributes to the evolution of organ pathologies and diseases during organismal aging. c) Furthermore, aging-associated alterations in systemic and extracellular factors derived from metabolic changes, microbiota alterations, chronic inflammation, senescent, or damaged cells might impinge on disease development and tumor initiation.
- Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
Cui** Y, Ma L, Schacke S, Yin JC, Hsueh YP, Jin H, Morrison** H
Hum Mol Genet 2021 (epub ahead of print) ** co-corresponding authors
- GMPPA defects cause a neuromuscular disorder with α-dystroglycan hyperglycosylation.
Franzka P, Henze H, Jung MJ, Schüler SC, Mittag S, Biskup K, Liebmann L, Kentache T, Morales J, Martínez B, Katona I, Herrmann T, Huebner AK, Hennings JC, Groth S, Gresing LJ, Horstkorte R, Marquardt T, Weis J, Kaether C, Mutchinick OM, Ori A, Huber O, Blanchard V, von Maltzahn J, Hübner CA
J Clin Invest 2021 (epub ahead of print)
- Correction: Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita Y, Rudolph KL
J Exp Med 2021, 218(1)
- The Peripheral Nervous System in Hematopoietic Stem Cell Aging.
Böhm L, Helbing DL, Oraha N, Morrison H
Mech Ageing Dev 2020, 191, 111329
- Optimization of blocking conditions for fluorescent Western blot.
Anal Biochem 2020, 593, 113598
- Control mechanisms of YAP activity
Dissertation 2020, Jena, Germany
- Hippo Signaling in Regeneration and Aging.
Elster D, von Eyss B
Mech Ageing Dev 2020, 189, 111280
- Identification of Undescribed Relb Expression Domains in the Murine Brain by New Relb:cre-katushka Reporter Mice.
Engelmann C, Riemann M, Carlstedt S, Grimlowski R, Andreas N, Koliesnik I, Meier E, Austerfield P, Haenold R
Dev Dyn 2020, 249(8), 983-97
- The Neurofibromatoses.
Farschtschi S, Mautner VF, McLean ACL, Schulz A, Friedrich R, Rosahl SK
Dtsch Arztebl Int 2020, 117(20), 354-60
- C-Fiber Loss as a Possible Cause of Neuropathic Pain in Schwannomatosis.
Farschtschi SC, Mainka T, Glatzel M, Hannekum AL, Hauck M, Gelderblom M, Hagel C, Friedrich RE, Schuhmann MU, Schulz A, Morrison H, Kehrer-Sawatzki H, Luhmann J, Gerloff C, Bendszus M, Bäumer P, Mautner VF
Int J Mol Sci 2020, 21(10)