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Home>Research>Subarea 3: Genetics and Epigenetics of Aging
Research focus of Subarea 3.

Subarea 3: Genetics and Epigenetics of Aging

The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.

The research is defined by five focus areas:

  • Comparative genomics in short- and long-lived models of aging,
  • Genomic engineering in N. furzeri,
  • Epigenetics of aging,
  • Non-coding RNAs in aging, and
  • Comparative transcriptomics of aging.

Research focus of Subarea 3.

To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.

Publications

(since 2016)

2009

  • Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri.
    Valenzano* DR, Kirschner* J, Kamber RA, Zhang E, Weber D, Cellerino A, Englert C, Platzer M, Reichwald K, Brunet A
    Genetics 2009, 183(4), 1385-95 * equal contribution

2008

  • Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
    Terzibasi* E, Valenzano* DR, Benedetti M, Roncaglia P, Cattaneo A, Domenici L, Cellerino A
    PLoS One 2008, 3(12), e3866 * equal contribution

2007

  • Neurophysiological correlates for the perception of facial sexual dimorphism.
    Cellerino A, Borghetti D, Valenzano DR, Tartarelli G, Mennucci A, Murri L, Sartucci F
    Brain Res Bull 2007, 71(5), 515-22 published during change of institution
  • The short-lived fish Nothobranchius furzeri as a new model system for aging studies.
    Terzibasi E, Valenzano DR, Cellerino A
    Exp Gerontol 2007, 42(1-2), 81-9 published during change of institution

2006

  • Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule.
    Valenzano DR, Cellerino A
    Cell Cycle 2006, 5(10), 1027-32 published during change of institution

2005

  • Annual fishes of the genus Nothobranchius as a model system for aging research.
    Genade T, Benedetti M, Terzibasi E, Roncaglia P, Valenzano DR, Cattaneo A, Cellerino A
    Aging Cell 2005, 4(5), 223-33 published during change of institution