Subarea 3: Genetics and Epigenetics of Aging

The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.

The research is defined by five focus areas:

  • Comparative genomics in short- and long-lived models of aging,
  • Genomic engineering in N. furzeri,
  • Epigenetics of aging,
  • Non-coding RNAs in aging, and
  • Comparative transcriptomics of aging.

Research focus of Subarea 3.

To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.

Publications

(since 2016)

2021

  • A marine Chlamydomonas sp. emerging as an algal model.
    Carrasco Flores D, Fricke M, Wesp V, Desirò D, Kniewasser A, Hölzer M, Marz M, Mittag M
    J Phycol 2021, 57(1), 54-69
  • EpiDope: A Deep Neural Network for linear B-cell epitope prediction.
    Collatz M, Mock F, Barth E, Hölzer M, Sachse K, Marz M
    Bioinformatics 2021 (epub ahead of print)
  • PoSeiDon: a Nextflow pipeline for the detection of evolutionary recombination events and positive selection.
    Hölzer M, Marz M
    Bioinformatics 2021 (epub ahead of print)
  • VIDHOP, viral host prediction with Deep Learning.
    Mock F, Viehweger A, Barth E, Marz M
    Bioinformatics 2021 (epub ahead of print)
  • Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in HPA stress axis.
    Sahm* A, Platzer M, Koch P, Henning Y, Bens M, Groth M, Burda H, Begall S, Ting S, Goetz M, Van Daele P, Staniszewska M, Klose J, Costa PF, Hoffmann** S, Szafranski** K, Dammann** P
    Elife 2021 (epub ahead of print) ** co-senior authors, * corresponding author
  • Tissue-specific Gene Expression Changes Are Associated with Aging in Mice.
    Srivastava* A, Barth* E, Ermolaeva MA, Guenther M, Frahm C, Marz** M, Witte** OW
    Genomics Proteomics Bioinformatics 2021 (epub ahead of print) * equal contribution, ** co-corresponding authors
  • HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration.
    Tapias* A, Lázaro* D, Yin* BK, Rasa SMM, Krepelova A, Kelmer Sacramento E, Grigaravicius P, Koch P, Kirkpatrick J, Ori A, Neri F, Wang ZQ
    Elife 2021 (epub ahead of print) * equal contribution

2020

  • NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients.
    Bertacchi M, Romano AL, Loubat A, Tran Mau-Them F, Willems M, Faivre L, Khau van Kien P, Perrin L, Devillard F, Sorlin A, Kuentz P, Philippe C, Garde A, Neri F, Di Giaimo R, Oliviero S, Cappello S, D'Incerti L, Frassoni C, Studer M
    EMBO J 2020, 39(13), e104163
  • NF-κB signaling in tanycytes mediates inflammation-induced anorexia.
    Böttcher M, Müller-Fielitz H, Sundaram SM, Gallet S, Neve V, Shionoya K, Zager A, Quan N, Liu X, Schmidt-Ullrich R, Haenold R, Wenzel J, Blomqvist A, Engblom D, Prevot V, Schwaninger M
    Mol Metab 2020, 39, 101022
  • Identification of Undescribed Relb Expression Domains in the Murine Brain by New Relb:cre-katushka Reporter Mice.
    Engelmann C, Riemann M, Carlstedt S, Grimlowski R, Andreas N, Koliesnik I, Meier E, Austerfield P, Haenold R
    Dev Dyn 2020, 249(8), 983-97