Subarea 3: Genetics and Epigenetics of Aging
The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.
The research is defined by five focus areas:
- Comparative genomics in short- and long-lived models of aging,
- Genomic engineering in N. furzeri,
- Epigenetics of aging,
- Non-coding RNAs in aging, and
- Comparative transcriptomics of aging.
Research focus of Subarea 3.
To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influ ence clonal mutation and epigenetic alterations through metabolites and other signals.
Publications
(since 2016)
2024
- [Genetics, epigenetics, and environmental factors in life expectancy-What role does nature-versus-nurture play in aging?].
Bierhoff H
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2024, 67(5), 521-7 - NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells.
Bottoni L, Minetti A, Realini G, Pio E, Giustarini D, Rossi R, Rocchio C, Franci L, Salvini L, Catona O, D'Aurizio R, Rasa M, Giurisato E, Neri F, Orlandini M, Chiariello M, Galvagni F
Oncogene 2024 (epub ahead of print) - Sex chromosome turnover in African annual killifishes of the genus Nothobranchius
Monika H, Pablo M, Anna CV, Ahmed AR, Sergey AS, Tomáš P, Marie A, Karolína J, Jana Š, Nikolas T, Marek J, Matyáš H, Liehr T, Martin R, Eugene YK, Petr R, Englert C, Petr N, Sember A
bioRxiv 2024, https://doi.org/10.1101/2024.03. - Viral challenges and adaptations between Central Arctic Ocean and atmosphere
Rahlff J, Westmeijer G, Weissenbach J, Antson A, Holmfeldt K
bioRxiv 2024, https://doi.org/10.1101/2024.03. - PAPAS promotes differentiation of mammary epithelial cells and suppresses breast carcinogenesis.
Ren S, Bai F, Schnell V, Stanko C, Ritsch M, Schenk T, Barth E, Marz M, Wang B, Pei XH, Bierhoff H
Cell Rep 2024 (epub ahead of print) - Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans.
Sharifi* S, Chaudhari* P, Martirosyan A, Eberhardt AO, Witt F, Gollowitzer A, Lange L, Woitzat Y, Okoli EM, Li H, Rahnis N, Kirkpatrick J, Werz O, Ori A, Koeberle A, Bierhoff** H, Ermolaeva** M
Nat Commun 2024, 15(1), 1702 * equal contribution, ** co-corresponding authors - Comprehensive survey of conserved RNA secondary structures in full-genome alignment of Hepatitis C virus.
Triebel S, Lamkiewicz K, Ontiveros N, Sweeney B, Stadler PF, Petrov AI, Niepmann M, Marz M
Sci Rep 2024, 14(1), 15145 - Maternal perceived stress and green spaces during pregnancy are associated with adult offspring gene (NR3C1 and IGF2/H19) methylation patterns in adulthood: A pilot study.
Vos S, Van den Bergh BRH, Martens DS, Bijnens E, Shkedy Z, Kindermans H, Platzer M, Schwab M, Nawrot TS
Psychoneuroendocrinology 2024 (epub ahead of print)
2023
- Localization and Characterization of Major Neurogenic Niches in the Brain of the Lesser-Spotted Dogfish Scyliorhinus canicula.
Bagnoli S, Chiavacci E, Cellerino A, Terzibasi Tozzini E
Int J Mol Sci 2023, 24(4), 3650 - Distribution of Brain-Derived Neurotrophic Factor in the Brain of the Small-Spotted Catshark Scyliorhinus canicula, and Evolution of Neurotrophins in Basal Vertebrates.
Chiavacci E, Bagnoli S, Cellerino A, Terzibasi Tozzini E
Int J Mol Sci 2023, 24(11), 9495
