Publications

2020

• Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.
  Buczak K, Kirkpatrick JM, Truckenmueller F, Santinha D, Ferreira L, Roessler S, Singer S, Beck** M, Ori** A
  Nat Protoc 2020, 15(9), 2956-79 ** co-corresponding authors
  
• Region-specific effects of aging on the small intestinal epithelium and the influence of dietary restriction
  Gebert N
  Dissertation 2020, Jena, Germany
  
• Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction.
  Gebert N, Cheng CW, Kirkpatrick JM, Di Fraia D, Yun J, Schädel P, Pace S, Garside GB, Werz O, Rudolph KL, Jasper H, Yilmaz ÖH, Ori A
  Cell Rep 2020, 31(4), 107565
  
• Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
  Kelmer Sacramento* E, Kirkpatrick* JM, Mazzetto* M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant PH, Huber W, Chondrogianni N, Vendruscolo M, Cellerino** A, Ori** A
  Mol Syst Biol 2020, 16(6), e9596 * equal contribution, ** co-corresponding authors
  
• The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
  Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T
  Autophagy 2020, 16(9), 1618-34
  
• Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.
  Pitrez PR, Estronca L, Monteiro LM, Colell G, Vazão H, Santinha D, Harhouri K, Thornton D, Navarro C, Egesipe AL, Carvalho T, Dos Santos RL, Lévy N, Smith JC, de Magalhães JP, Ori A, Bernardo A, De Sandre-Giovannoli A, Nissan X, Rosell A, Ferreira L
  Nat Commun 2020, 11(1), 4110
  
• Stem Cell Aging: The Upcoming Era of Proteins and Metabolites.
  Schüler* SC, Gebert* N, Ori A
  Mech Ageing Dev 2020 (epub ahead of print) * equal contribution
  

2019

• Quantitation of Reactive Acyl-CoA Species Mediated Protein Acylation by HPLC-MS/MS.
  Baldensperger T, Simone DS, Ori A, Glomb MA
  Anal Chem 2019, 91(19), 12336-43
  
• Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
  Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Haenold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita** Y, Rudolph** KL
  J Exp Med 2019, 216(1), 152-75 ** co-corresponding authors
  
• Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.
  Drucker E, Holzer K, Pusch S, Winkler J, Calvisi DF, Eiteneuer E, Herpel E, Goeppert B, Roessler S, Ori A, Schirmacher P, Breuhahn K, Singer S
  Cell Commun Signal 2019, 17(1), 159