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Research focus of Subarea 3.

Subarea 3: Genetics and Epigenetics of Aging

The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.

The research is defined by five focus areas:

  • Comparative genomics in short- and long-lived models of aging,
  • Genomic engineering in N. furzeri,
  • Epigenetics of aging,
  • Non-coding RNAs in aging, and
  • Comparative transcriptomics of aging.

Research focus of Subarea 3.

To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.

Publications

(since 2016)

2024

  • Quantitative mapping of proteasome interactomes and substrates using ProteasomeID.
    Bartolome A, Heiby* JC, Di Fraia* D, Heinze I, Knaudt H, Spaeth E, Omrani O, Minetti A, Hofmann M, Kirkpatrick JM, Dau** T, Ori** A
    Elife 2024, 13 * equal contribution, ** co-corresponding authors
  • [Genetics, epigenetics, and environmental factors in life expectancy-What role does nature-versus-nurture play in aging?].
    Bierhoff H
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2024, 67(5), 521-7
  • NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells.
    Bottoni L, Minetti A, Realini G, Pio E, Giustarini D, Rossi R, Rocchio C, Franci L, Salvini L, Catona O, D'Aurizio R, Rasa M, Giurisato E, Neri F, Orlandini M, Chiariello M, Galvagni F
    Oncogene 2024 (epub ahead of print)
  • Spatio-temporal variability of airborne viruses over sub-Antarctic South Georgia: Effects of sampling device and proximity of the ocean
    Das R, Malard L, Pearce DA, Rahlff J
    bioRxiv 2024, doi.org/10.1101/2024.08.23.60932
  • Epigenetic clock and lifespan prediction in the short-lived killifish Nothobranchius furzeri
    Giannuzzi C, Baumgart M, Neri F, Cellerino A
    bioRxiv 2024, https://doi.org/10.1101/2024.08.
  • Comprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain.
    Kumar NH, Kluever V, Barth E, Krautwurst S, Furlan M, Pelizzola M, Marz M, Fornasiero EF
    Nucleic Acids Res 2024, 52(6), 2865-85
  • Exploring the impact of primer length on efficient gene detection via high-throughput sequencing.
    Micheel J, Safrastyan A, Aron F, Wollny D
    Nat Commun 2024, 15(1), 5858
  • Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
    Minetti A, Omrani O, Brenner C, Allies G, Imada S, Rösler J, Khawaled S, Cansiz F, W.Meckelmann S, Gebert N, Heinze I, Lu J, Spengler K, Rasa M, Heller R, Yilmaz O, Tasdogan A, Neri F, Ori A
    bioRxiv 2024, https://doi.org/10.1101/2024.07.
  • Sex chromosome turnover in African annual killifishes of the genus Nothobranchius
    Monika H, Pablo M, Anna CV, Ahmed AR, Sergey AS, Tomáš P, Marie A, Karolína J, Jana Š, Nikolas T, Marek J, Matyáš H, Liehr T, Martin R, Eugene YK, Petr R, Englert C, Petr N, Sember A
    bioRxiv 2024, https://doi.org/10.1101/2024.03.
  • Viral challenges and adaptations between Central Arctic Ocean and atmosphere
    Rahlff J, Westmeijer G, Weissenbach J, Antson A, Holmfeldt K
    bioRxiv 2024, https://doi.org/10.1101/2024.03.