Subarea 3: Genetics and Epigenetics of Aging

The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.

The research is defined by five focus areas:

  • Comparative genomics in short- and long-lived models of aging,
  • Genomic engineering in N. furzeri,
  • Epigenetics of aging,
  • Non-coding RNAs in aging, and
  • Comparative transcriptomics of aging.

Research focus of Subarea 3.

To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.

Publications

(since 2016)

2020

  • NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients.
    Bertacchi M, Romano AL, Loubat A, Tran Mau-Them F, Willems M, Faivre L, Khau van Kien P, Perrin L, Devillard F, Sorlin A, Kuentz P, Philippe C, Garde A, Neri F, Di Giaimo R, Oliviero S, Cappello S, D'Incerti L, Frassoni C, Studer M
    EMBO J 2020 (epub ahead of print)
  • NF-κB signaling in tanycytes mediates inflammation-induced anorexia.
    Böttcher M, Müller-Fielitz H, Sundaram SM, Gallet S, Neve V, Shionoya K, Zager A, Quan N, Liu X, Schmidt-Ullrich R, Haenold R, Wenzel J, Blomqvist A, Engblom D, Prevot V, Schwaninger M
    Mol Metab 2020 (epub ahead of print)
  • Identification of Undescribed Relb Expression Domains in the Murine Brain by New Relb:cre-katushka Reporter Mice.
    Engelmann C, Riemann M, Carlstedt S, Grimlowski R, Andreas N, Koliesnik I, Meier E, Austerfield P, Haenold R
    Dev Dyn 2020 (epub ahead of print)
  • miR-182-5p is an evolutionarily conserved Tbx5 effector that impacts cardiac development and electrical activity in zebrafish.
    Guzzolino E, Pellegrino M, Ahuja N, Garrity D, D'Aurizio R, Groth M, Baumgart M, Hatcher CJ, Mercatanti A, Evangelista M, Ippolito C, Tognoni E, Fukuda R, Lionetti V, Pellegrini M, Cremisi F, Pitto L
    Cell Mol Life Sci 2020 (epub ahead of print)
  • PoSeiDon: a Nextflow pipeline for the detection of evolutionary recombination events and positive selection.
    Hölzer M, Marz M
    Bioinformatics 2020 (epub ahead of print)
  • Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
    Kelmer Sacramento* E, Kirkpatrick* JM, Mazzetto* M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant PH, Huber W, Chondrogianni N, Vendruscolo M, Cellerino** A, Ori** A
    Mol Syst Biol 2020, 16(6), e9596 * equal contribution, ** co-corresponding authors
  • ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling.
    Li B, Zhu C, Dong L, Qin J, Xiang W, Davidson AJ, Feng S, Wang Y, Shen X, Weng C, Wang C, Zhu T, Teng L, Wang J, Englert C, Chen J, Jiang H
    J Pathol 2020 (epub ahead of print)
  • VIDHOP, viral host prediction with Deep Learning.
    Mock F, Viehweger A, Barth E, Marz M
    Bioinformatics 2020 (epub ahead of print)
  • Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.
    Montesano* A, Felice* ED, Leggieri A, Palladino A, Lucini C, Scocco P, Girolamo Pd, Baumgart** M, D'Angelo** L
    J Clin Med 2020, 9(1) * equal contribution, ** co-corresponding authors
  • A comprehensive annotation and differential expression analysis of short and long non-coding RNAs in 16 bat genomes.
    Mostajo NF, Lataretu M, Krautwurst S, Mock F, Desirò D, Lamkiewicz K, Collatz M, Schoen A, Weber F, Marz M, Hölzer M
    NAR Genom Bioinform 2020, 2(1), lqz006