Former Research Group - Große



  • DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding.
    Szambowska A, Tessmer I, Kursula P, Usskilat C, Prus P, Pospiech H, Grosse F
    Nucleic Acids Res 2014, 42(4), 2308-19
  • Gap-directed translesion DNA synthesis of an abasic site on circular DNA templates by a human replication complex.
    Villani G, Shevelev I, Orlando E, Pospiech H, Syvaoja JE, Markkanen E, Hubscher U, Le Gac NT
    PLoS One 2014, 9(4), e93908


  • Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer.
    Li H, Hassona MD, Lack NA, Axerio-Cilies P, Leblanc E, Kanaan N, Frewin K, Singh K, Adomat H, Böhm KJ, Prinz H, Guns ET, Rennie PS, Cherkasov A
    Mol Cancer Ther 2013, 12(11), 2425-35
  • RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.
    Mills JR, Malina A, Lee T, Di Paola D, Larsson O, Miething C, Grosse F, Tang H, Zannis-Hadjopoulos M, Lowe SW, Pelletier J
    Blood 2013, 121(17), 3402-12
  • Heterozygous mutations in PALB2 cause DNA replication and damage response defects.
    Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech* H, Winqvist* R
    Nat Commun 2013, 4, 2578 * equal contribution
  • α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay.
    Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Böhm KJ, Winner B
    J Biol Chem 2013, 288(30), 21742-54
  • Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts.
    Rentzsch A, Kahlert V, Jahreis G, Schlott B, Schutkowski M, Malešević M, Fischer G
    Biol Chem 2013, 394(8), 1057-67


  • Synthesis and functional characterization of tridegin and its analogues: inhibitors and substrates of factor XIIIa.
    Böhm M, Kühl T, Hardes K, Coch R, Arkona C, Schlott B, Steinmetzer T, Imhof D
    ChemMedChem 2012, 7(2), 326-33
  • Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins.
    Kuhnert A, Schmidt U, Monajembashi S, Franke C, Schlott B, Grosse F, Greulich KO, Saluz HP, Hänel F
    J Cell Biochem 2012, 113(5), 1744-53
  • The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif.
    Ohlenschläger O, Kuhnert A, Schneider A, Haumann S, Bellstedt P, Keller H, Saluz HP, Hortschansky P, Hänel F, Grosse F, Görlach M, Pospiech H
    Nucleic Acids Res 2012, 40(17), 8309-24