Subarea 3: Genetics and Epigenetics of Aging
The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.
The research is defined by five focus areas:
- Comparative genomics in short- and long-lived models of aging,
- Genomic engineering in N. furzeri,
- Epigenetics of aging,
- Non-coding RNAs in aging, and
- Comparative transcriptomics of aging.
Research focus of Subarea 3.
To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.
Publications
(since 2016)
2018
- Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis.
Viana MVC, Sahm A, Góes Neto A, Figueiredo HCP, Wattam AR, Azevedo V
PLoS One 2018, 13(11), e0207304 - Limited scope for reproductive senescence in wild populations of a short-lived fish.
Vrtílek M, Žák J, Blažek R, Polačik M, Cellerino A, Reichard M
Naturwissenschaften 2018, 105(11-12), 68
2017
- Tissue-, sex- and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin like growth factor 2 imprinting control region.
Agba OB, Lausser L, Huse K, Bergmeier C, Jahn N, Groth M, Bens M, Sahm A, Gall M, Witte OW, Kestler HA, Schwab M, Platzer M
Physiol Genomics 2017, 49(11), 690-702 APSselect for distinction in scholarship in the Physiological Genomics - Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22.
Arruga F, Gizdic B, Bologna C, Cignetto S, Buonincontri R, Serra S, Vaisitti T, Gizzi K, Vitale N, Garaffo G, Mereu E, Diop F, Neri F, Incarnato D, Coscia M, Allan J, Piva R, Oliviero S, Furman RR, Rossi D, Gaidano G, Deaglio S
Leukemia 2017, 31(9), 1882-93 published during change of institution - PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p.
Audrito V, Serra S, Stingi A, Orso F, Gaudino F, Bologna C, Neri F, Garaffo G, Nassini R, Baroni G, Rulli E, Massi D, Oliviero S, Piva R, Taverna D, Mandalà M, Deaglio S
Oncotarget 2017, 8(9), 15894-911 published during change of institution - A miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri.
Baumgart* M, Barth* E, Savino A, Groth M, Koch P, Petzold A, Arisi I, Platzer M, Marz* M, Cellerino* A
BMC Genomics 2017, 18(1), 693 * equal contribution - Construction of a map-based reference genome sequence for barley, Hordeum vulgare L.
Beier S, Himmelbach A, Colmsee C, Zhang XQ, Barrero RA, Zhang Q, Li L, Bayer M, Bolser D, Taudien S, Groth M, Felder M, Hastie A, Šimková H, Staňková H, Vrána J, Chan S, Muñoz-Amatriaín M, Ounit R, Wanamaker S, Schmutzer T, Aliyeva-Schnorr L, Grasso S, Tanskanen J, Sampath D, Heavens D, Cao S, Chapman B, Dai F, Han Y, Li H, Li X, Lin C, McCooke JK, Tan C, Wang S, Yin S, Zhou G, Poland JA, Bellgard MI, Houben A, Doležel J, Ayling S, Lonardi S, Langridge P, Muehlbauer GJ, Kersey P, Clark MD, Caccamo M, Schulman AH, Platzer M, Close TJ, Hansson M, Zhang G, Braumann I, Li C, Waugh R, Scholz U, Stein N, Mascher M
Sci Data 2017, 4, 170044 - Development and application of RNA-seq bioinformatic tools to explore non-model organisms in ageing research
Bens M
Dissertation 2017, Jena, Germany - Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.
Bianchi FT, Tocco C, Pallavicini G, Liu Y, Vernì F, Merigliano C, Bonaccorsi S, El-Assawy N, Priano L, Gai M, Berto GE, Chiotto AMA, Sgrò F, Caramello A, Tasca L, Ala U, Neri F, Oliviero S, Mauro A, Geley S, Gatti M, Di Cunto F
Cell Rep 2017, 18(7), 1674-86 published during change of institution - Repeated intra-specific divergence in lifespan and ageing of African annual fishes along an aridity gradient.
Blažek R, Polačik M, Kačer P, Cellerino A, Řežucha R, Methling C, Tomášek O, Syslová K, Tozzini ET, Albrecht T, Vrtílek M, Reichard M
Evolution Int J Org Evolution 2017, 71(2), 386-402