Kaether Research Group



  • Trafficking and proteolytic processing of APP.
    Haass C, Kaether C, Thinakaran G, Sisodia S
    Cold Spring Harb Perspect Med 2012, 2(5), a006270
  • Accumulation of annexin A5 at the nuclear envelope is a biomarker of cellular aging.
    Klement K, Melle C, Murzik U, Diekmann S, Norgauer J, Hemmerich P
    Mech Ageing Dev 2012, 133(7), 508-22
  • Identification of novel regulators of notch signaling by image based screening
    Krämer AM
    Dissertation 2012, Jena, Germany
  • Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons.
    Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J
    J Neurosci 2012, 32(2), 738-45


  • Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.
    Fassler M, Li X, Kaether C
    J Biol Chem 2011, 286(44), 38390-6
  • Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death.
    Juenemann K, Weisse C, Reichmann D, Kaether C, Calkhoven CF, Schilling G
    Neurotox Res 2011, 20(2), 120-33
  • Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits.
    Valkova* C, Albrizio* M, Röder IV, Schwake M, Betto R, Rudolf** R, Kaether** C
    Proc Natl Acad Sci U S A 2011, 108(2), 621-5 * equal contribution, ** co-corresponding authors


  • ER retention signals in the [gamma]-secretase and their role in complex assembly
    Faßler M
    Dissertation 2010, Jena, Germany
  • Masking of transmembrane-based retention signals controls ER export of gamma-secretase.
    Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C
    Traffic 2010, 11(2), 250-8
  • Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.
    Friedrich* RP, Tepper* K, Rönicke R, Soom M, Westermann M, Reymann K, Kaether C, Fändrich M
    Proc Natl Acad Sci U S A 2010, 107(5), 1942-7 * equal contribution