Former Than Research Group (Until 2015)

Publications

2012

  • Röntgenstrukturanalyse des extrazellulären Cystein-reichen Bereichs des death receptor 6 (DR6) und die Entwicklung einer affinitätsbasierten Reinigung der Proproteinkonvertase Furin
    Küster M
    Dissertation 2012, Jena, Germany

2011

  • Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.
    Dislich B, Than ME, Lichtenthaler SF
    Biochem J 2011, 433(1), 75-83
  • Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors.
    Kuester M, Becker GL, Hardes K, Lindberg I, Steinmetzer T, Than ME
    Biol Chem 2011, 392(11), 973-81
  • The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP).
    Kuester M, Kemmerzehl S, Dahms SO, Roeser D, Than ME
    J Mol Biol 2011, 409(2), 189-201
  • New furin inhibitors based on weakly basic amidinohydrazones.
    Sielaff F, Than ME, Bevec D, Lindberg I, Steinmetzer T
    Bioorg Med Chem Lett 2011, 21(2), 836-40

2010

  • Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
    Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T
    J Med Chem 2010, 53(3), 1067-75
  • Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.
    Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME
    Proc Natl Acad Sci U S A 2010, 107(12), 5381-6
  • ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
    Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IRA, Capell A, Schmid B, Neumann M, Haass C
    EMBO J 2010, 29(16), 2841-57

2007

  • Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.
    Keil C, Maskos K, Than M, Hoopes JT, Huber R, Tan F, Deddish PA, Erdös EG, Skidgel RA, Bode W
    J Mol Biol 2007, 366(2), 504-16 published during change of institution

2006

  • X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.
    Rohr KB, Selwood T, Marquardt U, Huber R, Schechter NM, Bode W, Than ME
    J Mol Biol 2006, 357(1), 195-209 published during change of institution