Former Research Group - Than (until 2015)



  • Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA.
    Dienemann C, Coburger I, Mehmedbasic A, Andersen OM, Than ME
    Biochemistry 2015, 54(15), 2490-9
  • Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.
    Fittler H, Depp A, Avrutina O, Dahms SO, Than ME, Empting M, Kolmar H
    Chembiochem 2015, 16(17), 2441-4
  • Novel Furin Inhibitors with Potent Anti-infectious Activity.
    Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T
    ChemMedChem 2015, 10(7), 1218-31
  • The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain.
    Hoefgen S, Dahms SO, Oertwig K, Than ME
    J Mol Biol 2015, 427(2), 433-42
  • Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
    Lu Y, Hardes K, Dahms SO, Böttcher-Friebertshäuser E, Steinmetzer T, Than ME, Klenk HD, Garten W
    Antiviral Res 2015, 120, 89-100
  • Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
    Reichwald* K, Petzold* A, Koch* P, Downie* BR, Hartmann* N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Görlach M, Than ME, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino** A, Englert** C, Platzer** M
    Cell 2015, 163(6), 1527-38 * equal contribution, ** co-senior authors, featured in Cell Preview by Vanisha Lakhina and Coleen T. Murphy: Genome Sequencing Fishes out Longevity Genes. Cell. 2015 163(6):1312-3,Nature News by Ewen Callaway: Short-lived fish may hold clues to human age


  • Novel Insights into Structure and Function of Factor XIIIa-Inhibitor Tridegin.
    Böhm M, Bäuml CA, Hardes K, Steinmetzer T, Roeser D, Schaub Y, Than ME, Biswas A, Imhof D
    J Med Chem 2014, 57(24), 10355-65
  • The structural biology of the amyloid precursor protein APP - a complex puzzle reveals its multi-domain architecture.
    Coburger I, Hoefgen S, Than ME
    Biol Chem 2014, 395(5), 485-98 Featured in Global Medical Discovery
  • X-ray structures of human furin in complex with competitive inhibitors.
    Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME
    ACS Chem Biol 2014, 9(5), 1113-18
  • Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain.
    Hoefgen S, Coburger I, Roeser D, Schaub Y, Dahms S, Than M
    J Struct Biol 2014, 187(1), 30-7