Publications

2022

• CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.
  Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Dang Do AN, Porter FD, Ori A, Sabatini DM, Abu-Remaileh M
  Nature 2022, 609(7929), 1005-11
  
• Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction.
  Rasa* SMM, Annunziata* F, Krepelova A, Nunna S, Omrani O, Gebert N, Adam L, Käppel S, Höhn S, Donati G, Jurkowski TP, Rudolph KL, Ori A, Neri F
  Cell Rep 2022, 39(13), 111017 * equal contribution
  
• PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
  Schnoeder TM, Schwarzer A, Jayavelu AK, Hsu CJ, Kirkpatrick J, Döhner K, Perner F, Eifert T, Huber N, Arreba-Tutusaus P, Dolnik A, Assi SA, Nafria M, Jiang L, Dai YT, Chen Z, Chen SJ, Kellaway SG, Ptasinska A, Ng ES, Stanley EG, Elefanty AG, Buschbeck M, Bierhoff H, Brodt S, Matziolis G, Fischer KD, Hochhaus A, Chen CW, Heidenreich O, Mann M, Lane SW, Bullinger L, Ori A, Eyss Bv, Bonifer C, Heidel F
  Blood 2022, 139(7), 1080-97
  
• Single-cell atlas of the aging mouse colon.
  Širvinskas D, Omrani O, Lu J, Rasa M, Krepelova A, Adam L, Kaeppel S, Sommer F, Neri F
  iScience 2022, 25(5), 104202
  

2021

• Iron Oxide Nanoparticles Carrying 5-Fluorouracil in Combination with Magnetic Hyperthermia Induce Thrombogenic Collagen Fibers, Cellular Stress, and Immune Responses in Heterotopic Human Colon Cancer in Mice.
  Dabaghi M, Rasa SMM, Cirri E, Ori A, Neri F, Quaas R, Hilger I
  Pharmaceutics 2021, 13(10)
  
• Tnfaip2/exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasis.
  Deb S, Felix DA, Koch P, Deb MK, Szafranski K, Buder K, Sannai M, Groth M, Kirkpatrick J, Pietsch S, Gollowitzer A, Groß A, Riemenschneider P, Koeberle A, González-Estévez** C, Rudolph** KL
  EMBO Rep 2021, 22(1), e49328 ** co-corresponding authors
  
• Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
  Di Sanzo S
  Dissertation 2021, Jena, Germany
  
• Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation.
  Di Sanzo* S, Spengler* K, Leheis A, Kirkpatrick JM, Rändler TL, Baldensperger T, Dau T, Henning C, Parca L, Marx C, Wang ZQ, Glomb MA, Ori** A, Heller** R
  Nat Commun 2021, 12(1), 6743 * equal contribution, ** co-senior authors
  
• GMPPA defects cause a neuromuscular disorder with α-dystroglycan hyperglycosylation.
  Franzka P, Henze* H, Jung* MJ, Schüler SC, Mittag S, Biskup K, Liebmann L, Kentache T, Morales J, Martínez B, Katona I, Herrmann T, Huebner AK, Hennings JC, Groth S, Gresing LJ, Horstkorte R, Marquardt T, Weis J, Kaether C, Mutchinick OM, Ori A, Huber O, Blanchard V, von Maltzahn J, Hübner CA
  J Clin Invest 2021, 131(9), e139076 * equal contribution
  
• The Hematopoietic Bone Marrow Niche Ecosystem.
  Fröbel J, Landspersky T, Percin G, Schreck C, Rahmig S, Ori A, Nowak D, Essers M, Waskow C, Oostendorp RAJ
  Front Cell Dev Biol 2021, 9, 705410