Publications

2023

• Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony.
  Ceanga M, Rahmati V, Haselmann H, Schmidl L, Hunter D, Brauer AK, Liebscher S, Kreye J, Prüss H, Groc L, Hallermann S, Dalmau J, Ori A, Heckmann M, Geis C
  Cell Rep 2023 (epub ahead of print)
  
• Automated workflow for BioID improves reproducibility and identification of protein-protein interactions
  Cirri E, Knaudt H, Di Fraia D, Pömpner N, Rahnis N, Heinze I, Ori** A, Dau** T
  bioRxiv 2023, 10.1101/2023.09.08.556804 ** co-corresponding authors
  
• A comprehensive atlas of the aging vertebrate brain reveals signatures of progressive proteostasis dysfunction
  Di Fraia* D, Marino* A, Ho Lee* J, Kelmer Sacramento E, Baumgart M, Bagnoli S, Tomaz da Silva P, Kumar Sahu A, Siano G, Tiessen M, Terzibasi-Tozzini E, Gagneur J, Frydman** J, Cellerino** A, Ori** A
  bioRxiv 2023, 10.1101/2023.07.20.549210 * equal contribution, ** co-corresponding authors
  
• Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex.
  Franzka P, Schüler SC, Kentache T, Storm R, Bock A, Katona I, Weis J, Buder K, Kaether C, Hübner CA
  Biomedicines 2023, 11(1), 146.doi: 10.3390/biomedicines110
  
• Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury
  Helbing DL, Haas F, Cirri E, Rahnis N, Thuy Dung Dau T, Kelmer Sacramento E, Oraha N, Böhm L, Morrison H, Bauer R
  bioRxiv 2023, 10.1101/2023.04.13.536755
  
• Membrane shapers from two distinct superfamilies cooperate in the development of neuronal morphology.
  Izadi M, Wolf D, Seemann E, Ori A, Schwintzer L, Steiniger F, Kessels MM, Qualmann B
  J Cell Biol 2023, 222(8)
  
• IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.
  Omrani* O, Krepelova* A, Rasa SMM, Syrvinskas D, Lu J, Annunziata F, Garside G, Bajwa S, Reinhardt S, Adam L, Käppel S, Ducano N, Donna D, Ori A, Oliviero S, Rudolph KL, Neri F
  Nat Commun 2023, 14(1), 6109 * equal contribution
  
• Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging.
  Schädel P, Czapka A, Gebert N, Jacobsen ID, Ori** A, Werz** O
  Aging Cell 2023, 22(7), e13856 ** co-corresponding authors
  
• Short-Term Caloric Restriction and Subsequent Re-Feeding Compromise Liver Health and Associated Lipid Mediator Signaling in Aged Mice.
  Schädel P, Wichmann-Costaganna M, Czapka A, Gebert N, Ori A, Werz O
  Nutrients 2023, 15(16), 3660
  
• Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
  Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang Y, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colon-Mercado J, Reyes JF, Ryan VH, Nelson MP, Cook C, Li Z, Screven L, Kwan JY, Shantaraman A, Ping L, Koike Y, Oskarsson BR, Staff N, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Rohrer J, Malaspina A, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME
  bioRxiv 2023