Publications

2024

• SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling.
  Weiler SME, Bissinger M, Rose F, von Bubnoff F, Lutz T, Ori A, Schirmacher P, Breuhahn K
  Cancer Lett 2024, 584, 216637
  

2023

• Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony.
  Ceanga M, Rahmati V, Haselmann H, Schmidl L, Hunter D, Brauer AK, Liebscher S, Kreye J, Prüss H, Groc L, Hallermann S, Dalmau J, Ori A, Heckmann M, Geis C
  Cell Rep 2023, 42(10), 113166
  
• Integrated omics approaches to study protein complexes in neuronal differentiation and brain aging
  Di Fraia D
  Dissertation 2023, Jena, Germany
  
• Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain
  Di Fraia* D, Marino* A, Ho Lee* J, Kelmer Sacramento E, Baumgart M, Bagnoli S, Tomaz da Silva P, Kumar Sahu A, Siano G, Tiessen M, Terzibasi-Tozzini E, Gagneur J, Frydman** J, Cellerino** A, Ori** A
  bioRxiv 2023, 10.1101/2023.07.20.549210 * equal contribution, ** co-corresponding authors
  
• Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex.
  Franzka P, Schüler SC, Kentache T, Storm R, Bock A, Katona I, Weis J, Buder K, Kaether C, Hübner CA
  Biomedicines 2023, 11(1), 146.doi: 10.3390/biomedicines110
  
• Membrane shapers from two distinct superfamilies cooperate in the development of neuronal morphology.
  Izadi M, Wolf D, Seemann E, Ori A, Schwintzer L, Steiniger F, Kessels MM, Qualmann B
  J Cell Biol 2023, 222(8), e202211032
  
• Remodeling of the protein ubiquitylation landscape in the aging vertebrate brain
  Marino* A, Di Fraia* D, Panfilova D, Kumar Sahu A, Ori A
  bioRxiv 2023, 10.1101/2023.12.02.569713 * equal contribution
  
• IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.
  Omrani* O, Krepelova* A, Rasa SMM, Sirvinskas D, Lu J, Annunziata F, Garside G, Bajwa S, Reinhardt S, Adam L, Käppel S, Ducano N, Donna D, Ori A, Oliviero S, Rudolph KL, Neri F
  Nat Commun 2023, 14(1), 6109 * equal contribution
  
• Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging.
  Schädel P, Czapka A, Gebert N, Jacobsen ID, Ori** A, Werz** O
  Aging Cell 2023, 22(7), e13856 ** co-corresponding authors
  
• Short-Term Caloric Restriction and Subsequent Re-Feeding Compromise Liver Health and Associated Lipid Mediator Signaling in Aged Mice.
  Schädel P, Wichmann-Costaganna M, Czapka A, Gebert N, Ori A, Werz O
  Nutrients 2023, 15(16), 3660