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Core Facilites and Core Services

At the beginning of 2016, a “core” structure was put into effect that organized facility and service units as independent organizational entities from FLI’s research groups. A number of technology platforms (e.g. sequencing, mass spectrometry) grew out of individual methodological requirements for single research groups in the last years but developed into semiautonomous substructures. As consequence of re-focused research activities and the concomitant advent of new research groups at FLI, those units increasingly had to serve many FLI groups and collaborative research efforts in the Jena research area.

To accommodate this development and to increase efficiency as well as transparency for users, facility personnel and for administrative processes, it came natural to re-organize such activities into independent units as “FLI Core Facilities and Services” and to phase out infrastructures considered non-essential for FLI’s research focus (X-ray crystallography and NMR spectroscopy).

FLI’s Core Facilities (CF) are managed by a CF Manager and are each scientifically guided in their activities and development by an FLI Group Leader, as Scientific Supervisor. The animal facilities comprising fish, mouse and transgenesis are run separately, as they involve a more complex organizational structure. Basic Core Services (CS) are directly led by the Head of Core (HC), who in turn is supported by individual CS Managers.

All facilities and services, including animal facilities, have a valuable contribution to FLI’s research articles; e.g. from 2016–2018, to 54% of all peer reviewed research publications. 

Overview Core Facilities & Services

Overview Core Facilities and Core Services at FLI.

Publications

(since 2016)

2023

  • In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis.
    Matos-Rodrigues G, Barroca V, Muhammad AA, Dardillac E, Allouch A, Koundrioukoff S, Lewandowski D, Despras E, Guirouilh-Barbat J, Frappart L, Kannouche P, Dupaigne P, Le Cam E, Perfettini JL, Romeo PH, Debatisse M, Jasin M, Livera G, Martini E, Lopez BS
    EMBO J 2023, 42(20), e110844
  • Analysis of different strains of the turquoise killifish Nothobranchius furzeri identifies transcriptomic signatures associated with heritable lifespan differences
    Mazzetto M, Reichwald K, Kelmer Sacramento E, Koch P, Ori A, Groth M, Cellerino A
    bioRxiv 2023, 10.1101/2023.11.20.567823
  • The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination.
    Mühlenbruch L, Abou-Kors T, Dubbelaar ML, Bichmann L, Kohlbacher O, Bens M, Thomas J, Ezić J, Kraus JM, Kestler HA, von Witzleben A, Mytilineos J, Fürst D, Engelhardt D, Doescher J, Greve J, Schuler PJ, Theodoraki MN, Brunner C, Hoffmann TK, Rammensee HG, Walz JS, Laban S
    Br J Cancer 2023, 128(9), 1777-87
  • The Tgf-β family member Gdf6Y determines the male sex in Nothobranchius furzeri by suppressing oogenesis-inducing genes
    Richter A, Mörl H, Thielemann M, Kleemann M, Geißen R, Schwarz R, Albertz C, Koch P, Petzold A, Groth M, Hartmann N, Herpin A, Englert C
    bioRxiv 2023, 10.1101/2023.05.26.542338
  • Gene regulatory network inference with popInfer reveals dynamic regulation of hematopoietic stem cell quiescence upon diet restriction and aging.
    Rommelfanger* MK, Behrends* M, Chen Y, Martinez J, Bens M, Xiong L, Rudolph** KL, MacLean** AL
    bioRxiv 2023, 10.1101/2023.04.18.537360 * equal contribution, ** co-corresponding authors
  • Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes.
    Schwab K, Coronel L, Riege K, Sacramento EK, Rahnis N, Häckes D, Cirri E, Groth M, Hoffmann S, Fischer M
    CELL DEATH DISCOV 2023, 9(1), 80
  • Tau alters global gene expression affecting chromatin in the early stages of Alzheimer’s disease
    Siano* G, Varisco* M, Terrigno M, Wang C, Groth M, Galas MC, Hoozemans JJM, Cellerino A, Cattaneo** A, Di Primio** C
    bioRxiv 2023, 10.1101/2023.11.17.567548 * equal contribution, ** co-senior authors
  • Light and prey influence the abundances of two rhodopsins in the dinoflagellate Oxyrrhis marina.
    Westermann M, Hoischen C, Wöhlbrand L, Rabus R, Rhiel E
    Protoplasma 2023, 260(2), 529-44
  • Exploring the Diversity of Plant-Associated Viruses and Related Viruses in Riverine Freshwater Samples Collected in Berlin, Germany.
    Zell R, Groth M, Selinka L, Selinka HC
    Pathogens 2023, 12(12)
  • Hepeliviruses in two waterbodies in Berlin, Germany.
    Zell R, Groth M, Selinka L, Selinka HC
    Arch Virol 2023, 168(1), 9