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Core Facilites and Core Services

At the beginning of 2016, a “core” structure was put into effect that organized facility and service units as independent organizational entities from FLI’s research groups. A number of technology platforms (e.g. sequencing, mass spectrometry) grew out of individual methodological requirements for single research groups in the last years but developed into semiautonomous substructures. As consequence of re-focused research activities and the concomitant advent of new research groups at FLI, those units increasingly had to serve many FLI groups and collaborative research efforts in the Jena research area.

To accommodate this development and to increase efficiency as well as transparency for users, facility personnel and for administrative processes, it came natural to re-organize such activities into independent units as “FLI Core Facilities and Services” and to phase out infrastructures considered non-essential for FLI’s research focus (X-ray crystallography and NMR spectroscopy).

FLI’s Core Facilities (CF) are managed by a CF Manager and are each scientifically guided in their activities and development by an FLI Group Leader, as Scientific Supervisor. The animal facilities comprising fish, mouse and transgenesis are run separately, as they involve a more complex organizational structure. Basic Core Services (CS) are directly led by the Head of Core (HC), who in turn is supported by individual CS Managers.

All facilities and services, including animal facilities, have a valuable contribution to FLI’s research articles; e.g. from 2016–2018, to 54% of all peer reviewed research publications. 

Overview Core Facilities & Services

Overview Core Facilities and Core Services at FLI.

Publications

(since 2016)

2025

  • DNA damage response regulator ATR licenses PINK1-mediated mitophagy.
    Marx* C, Qing* X, Gong* Y, Kirkpatrick J, Siniuk K, Beznoussenko GV, Kidiyoor GR, Kirtay M, Buder K, Koch P, Westermann M, Bruhn C, Brown EJ, Xu X, Foiani M, Wang ZQ
    Nucleic Acids Res 2025, 53(5), gkaf178 * equal contribution
  • Analysis of different strains of the turquoise killifish identify transcriptomic signatures associated with heritable lifespan differences.
    Mazzetto M, Reichwald K, Koch P, Groth M, Cellerino A
    J Gerontol A Biol Sci Med Sci 2025, 80(7), glae255
  • Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.
    Minetti* A, Omrani* O, Brenner C, Cansiz F, Imada S, Rösler J, Khawaled S, Allies G, Meckelmann SW, Gebert N, Heinze I, Rahnis N, Lu J, Spengler K, Rasa M, Cirri E, Heller R, Yilmaz Ö, Tasdogan A, Neri** F, Ori** A
    Nat Cell Biol 2025 (epub ahead of print) * equal contribution, ** co-senior authors
  • Inhba, Homer1 and Bdnf are major targets of transcriptomic dysregulation by neurodegenerative disease-associated excitotoxic NMDA receptor signaling.
    Oberländer K, Pruunsild P, Koch P, Yan J, Szafranski K, Bading H
    Commun Biol 2025, 8(1), 1743
  • Replication stress responses in human lymphocytes change sex-specifically during aging.
    Rall-Scharpf M, Schlotter D, Koch P, Szafranski K, Groth M, Sahm A, Biber S, Castaño BA, Heitmeir B, Zengerling F, Deniz M, Dallmeier D, Braig S, Bonig H, Milyavsky M, Pospiech H, Wiesmüller L
    Nucleic Acids Res 2025, 53(11), gkaf498
  • CCB79 is a primate-specific cilium initiation factor essential to maintain neural progenitor diversity in developing brain tissue
    Rathinam D, Jadhav V, Wasim S, Elkahwagy D, Altinisik N, Cicek E, Borkar T, Mariappan A, Suhas Vinchure O, Poempner N, Zhao Z, Alsolami S, Li M, Ptok J, Eggeling C, Tariq M, Giovanna Riparbelli M, Cirri E, Callaini G, Nürnberg P, Gabriel E, Gopalakrishnan J
    bioRxiv 2025, https://doi.org/10.1101/2025.08.
  • The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.
    Richter* A, Mörl H, Thielemann M, Kleemann M, Geißen R, Schwarz R, Albertz C, Koch P, Petzold A, Kroll T, Groth M, Hartmann N, Herpin A, Englert* C
    Nat Commun 2025, 16(1), 540 * corresponding author
  • Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer's disease stages.
    Siano G, Varisco M, Terrigno M, Wang C, Scarlatti A, Iannone V, Groth M, Galas MC, Hoozemans JJM, Cellerino A, Cattaneo A, Di Primio C
    Front Cell Dev Biol 2025, 12, 1459573
  • NanTex enables computational multiplexing and phenotyping of organelles across super-resolution modalities
    T.L.Vogler B, J.Gentsch G, Carravilla P, A.Helmerich D, C.Heiby J, Reglinski K, Durso W, Klein T, Hildebrandt F, Zahid R, Spengler K, Heller R, Kaether C, Sauer M, Eggeling C, Franke C
    bioRxiv 2025, https://doi.org/10.1101/2025.09.
  • Gene regulation by convergent promoters.
    Wiechens E, Vigliotti* F, Siniuk* K, Schwarz R, Schwab K, Riege K, van Bömmel A, Görlich I, Bens M, Sahm A, Groth M, Sammons MA, Loewer A, Hoffmann** S, Fischer** M
    Nat Genet 2025, 57(1), 206-17 * equal contribution, ** co-corresponding authors