Neri Research Group
Selected Publications
- Intragenic DNA methylation prevents spurious transcription initiation.
Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, Maldotti M, Anselmi F, Oliviero S
Nature 2017, 543(7643), 72-7 - Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics.
Neri* F, Incarnato* D, Krepelova A, Rapelli S, Anselmi F, Parlato C, Medana C, Dal Bello F, Oliviero S
Cell Rep 2015, 10(5), 674–683 * equal contribution - TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway.
Neri F, Dettori D, Incarnato D, Krepelova A, Rapelli S, Maldotti M, Parlato C, Paliogiannis P, Oliviero S
Oncogene 2015, 34(32), 4168-76 - Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.
Neri* F, Krepelova* A, Incarnato D, Maldotti M, Parlato C, Galvagni F, Matarese F, Stunnenberg HG, Oliviero S
Cell 2013, 155(1), 121-34 * equal contribution - Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.
Neri F, Incarnato D, Krepelova A, Rapelli S, Pagnani A, Zecchina R, Parlato C, Oliviero S
Genome Biol 2013, 14(8), R91
Publications at FLI
2025
- Iron homeostasis and cell clonality drive cancer-associated intestinal DNA methylation drift in aging.
Krepelova A, Rasa M, Annunziata F, Lu J, Giannuzzi C, Omrani O, Wyart E, Porporato PE, Ansari I, Bilenko D, Bergman Y, Neri F
Nat Aging 2025 (epub ahead of print) - Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.
Minetti* A, Omrani* O, Brenner C, Cansiz F, Imada S, Rösler J, Khawaled S, Allies G, Meckelmann SW, Gebert N, Heinze I, Rahnis N, Lu J, Spengler K, Rasa M, Cirri E, Heller R, Yilmaz Ö, Tasdogan A, Neri** F, Ori** A
Nat Cell Biol 2025 (epub ahead of print) * equal contribution, ** co-senior authors - N-acetyl-l-cysteine ethyl ester (NACET) induces the transcription factor NRF2 and prevents retinal aging and diabetic retinopathy.
Realini G, Amato R, Rasa M, Ceccatelli R, Cannavale A, Bottoni L, Marchini F, Minetti A, Giustarini D, Canovai A, Melecchi A, Elia I, Krepelova A, Annunziata F, Cammalleri M, Rossi R, Tosi GM, Orlandini M, Chiariello M, Neri F, Dal Monte M, Galvagni F
Redox Biol 2025 (epub ahead of print)
2024
- Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
Minetti A, Omrani O, Brenner C, Allies G, Imada S, Rösler J, Khawaled S, Cansiz F, W.Meckelmann S, Gebert N, Heinze I, Lu J, Spengler K, Rasa M, Heller R, Yilmaz O, Tasdogan A, Neri F, Ori A
bioRxiv 2024, https://doi.org/10.1101/2024.07. - Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
Saggau C, Bacher P, Esser D, Rasa M, Meise S, Mohr N, Kohlstedt N, Hutloff A, Schacht SS, Dargvainiene J, Martini GR, Stürner KH, Schröder I, Markewitz R, Hartl J, Hastermann M, Duchow A, Schindler P, Becker M, Bautista C, Gottfreund J, Walter J, Polansky JK, Yang M, Naghavian R, Wendorff M, Schuster EM, Dahl A, Petzold A, Reinhardt S, Franke A, Wieczorek M, Henschel L, Berger D, Heine G, Holtsche M, Häußler V, Peters C, Schmidt E, Fillatreau S, Busch DH, Wandinger KP, Schober K, Martin R, Paul F, Leypoldt F, Scheffold A
Immunity 2024, 57(10), 2416-32
2023
- DNA methylation controls hematopoietic stem cell aging.
Krepelova A, Neri F
Nat Aging 2023, 3(11), 1320-2 - Interaction between epithelial cells and immune cells in the intestine during aging
Lu J
Dissertation 2023, Jena, Germany - IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.
Omrani* O, Krepelova* A, Rasa SMM, Sirvinskas D, Lu J, Annunziata F, Garside G, Bajwa S, Reinhardt S, Adam L, Käppel S, Ducano N, Donna D, Ori A, Oliviero S, Rudolph KL, Neri F
Nat Commun 2023, 14(1), 6109 * equal contribution
2022
- Paneth cells drive intestinal stem cell competition and clonality in aging and calorie restriction
Annunziata F, Rasa SMM, Krepelova A, Lu J, Minetti A, Omrani O, Nunna S, Adam L, Käppel S, Neri F
Eur J Cell Biol 2022, 101(4), 151282 - The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2.
Ehsani M, Bartsch S, Rasa SMM, Dittmann J, Pungsrinont T, Neubert L, Huettner SS, Kotolloshi R, Schindler K, Ahmad A, Mosig AS, Adam L, Ori A, Neri F, Berndt A, Grimm MO, Baniahmad A
Oncogene 2022, 41(23), 3263-77



