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Neurogenesis For brain development, neural stem cells have to be strictly controlled. The modelling of chromatin (the material which chromosomes consist of) through epigenetic mechanisms is crucial

302. DFG Research Training Groups

The anti-aging protein Klotho is strongly expressed in kidney and choroid plexus (CP). In kidney, Klotho full length functions as a co-receptor for the hormone FGF23. In addition, the external part

303. DFG Research Grants - DFG Research Grants

DFG Research Grants ATL gene family: How mutations in ER-shaping proteins cause axonopathy Peripheral neuropathies, including Small Fiber Neuropathy (SFN), affect millions and lead to chronic pain

304. DFG Priority Programm

Mitochondria import approximately 1,000 precursor proteins produced on cytosolic ribosomes, guided by cytosolic chaperones like Hsp70 and J-domain proteins. The translocase of the outer membrane

305. Research Projects

ATR (ATM- and Rad3-related) and NBS (Niemegen Breakage Syndrome) are key enzymes in the DNA damage response (DDR). Mutations in these genes induce degenerative diseases involving different levels of

306. Research Projects

Hematopoietic stem cells (HSCs) are maintained in quiescent state, which is required to maintain functional HSCs also during aging. Previous work from our team members revealed that telomere

307. Research Projects

The pentameric acetylcholine receptor (AChR) on skeletal muscle fibers decodes the contraction signal from the motor neuron. Our previous work revealed that Rer1 is a sorting receptor of the early

308. Research Projects

Peripheral nerves (PNs) have a remarkable capacity to regenerate, which depends on both axonal regrowth and dedifferentiation of Schwann cells into remyelinating cells. Aging strongly impairs PN

309. Marz - Marz Associated Research Group

Marz Associated Research Group Non-coding RNAs in Aging: The Regulation of Aging The group of Manja Marz is associated to the FLI as a cooperation group between the Friedrich Schiller University

310. Sühnel (retired) - Former Research Group - Sühnel (until 2011)

Former Research Group - Sühnel (until 2011) Biocomputing: Structural bioinformatics and computational genomics Dr. Jürgen Sühnel has retired as FLI Group Leader in June 2011. He was Coordinator of