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551. Publications - Project Biochemistry (until 2023)

Project Biochemistry (until 2023) Publications

Project Biochemistry

How do hereditary mutations in genes of the BRCA pathway lead to early onset of breast cancer? And how does the imbalance between DNA replication and recombination contribute to genomic…

554. Project Biochemistry

How does DNA replication stress promote genome destabilisation? DNA replication stress has been identified as a key factor leading to genomic instability and cancer. The number of DNA replication…

555. Project Biochemistry

What are the limits of mutation rates in human cells and how can mutation rates be control during aging and cancer? In a more recent line of research we look at the rates of mutations during DNA…

556. Project Biochemistry

What are the molecular functions of individual replication proteins? A longstanding research interest of our project group is the characterization of factors involved in DNA replication and…

557. Project Biochemistry

Find here the Publications of the Project Biochemistry: Publications

558. Project Biochemistry

AgingComb - Investigation of genome aging using high-throughput analysis of DNA replication and recombination Numerous studies in recent years point to the importance of progressive damage to the…

559. Project Biochemistry

References: Nikkilä, J. et al. (2013). Heterozygous mutations in PALB2 cause DNA replication and damage response defects, Nat Commun, 4, 2578. [PubMed] Obermeier, K. et al. (2016). Heterozygous…

560. Project Biochemistry

References: Hampp, S. et al. (2016). A DNA damage tolerance pathway involving DNA polymerase iota and the tumor suppressor p53 regulates DNA replication fork progression, Proc Natl Acad Sci U S A,…