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4511 results:
2971. Last Projects  
Our protein target oriented research often results in the necessity to establish, extend or to adapt new protein-crystallographic methods such as the development of an element-specific electron…  
2972. Last Projects  
We recently solved the crystal structure of the extracellular domain of the orphan death receptor six (DR6), as part of our investigations on the molecular interaction of APP with signalling…  
2973. Last Projects  
The respective effect on the interaction of APP is only seen for its binding of extracellular but not of intracellular partners of APP, consistent with a regulation of these interactions by the…  
2974. Last Projects  
Our biochemical and crystallographic data on the E2-domain of APP identified a metal-dependent molecular switch located within this part of APP. Four evolutionary highly conserved histidine residues…  
2975. Last Projects  
This E1-based dimerization of APP is induced and stabilized by the interaction with heparin, probably mimicking the physiologically more abundant heparan sufate proteglycanes (HSPGs). The…  
2976. Last Projects  
Our crystal structure of the entire E1-domain of APP shows that the two constituting subdomains called growth factor like domain (GFLD) and copper binding domain (CuBD) form one rigid structural and…  
2977. Last Projects  
Dimerization of APP is widely believed to be central to its physiologic function and to its processing in AD, influencing e.g., the A?-generation, the APP-ECM and the APP-based cell-cell interaction…  
2978. Last Projects  
We found that both E1 and E2 are able to form weak dimeric contacts, but only E1 can interact with short heparin chains in a way that pre-existing protein-protein-contacts get stabilized. Thus,…  
2979. Current Projects and Team - Kaether Research Group  
Kaether Research Group Current Projects "Anti-Aging" Hormone Klotho When the ectodomain of the membrane protein "Klotho" is enzymatically cleaved, Klotho circulates as…  
2980. Current Projects and Team  
Notch in Neurons The Notch receptor is essential for development, but also involved in learning and memory. However, it’s also known that its hyper activation leads to carcinogenesis. We study …  
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