We have established that a reduction in NF2 gene dosage in axons causes damage resulting in axonal atrophy, which in turn causes neuropathic symptoms in mice. From this, we could infer that the…
Morrison Research Group
Current Projects
Peripheral Nerve Regeneration and Aging
It is accepted that the aging process significantly impairs the ability of peripheral nerves to regenerate after…
Merlin is encoded by the neurofibromin 2 tumor suppressor gene. Although mutations in this gene were found to be the genetic cause of NF2, we still lack a complete understanding of the action of…
The Function of Poly(ADP-Ribosyl)ation
Poly(ADP-ribosyl)ation – called PARylation also – is the fasted reaction on DNA damage, especially on single-strand breaks and replication stress.…
Neurogenesis
For brain development, neural stem cells have to be strictly controlled. The modelling of chromatin (the material which chromosomes consist of) through epigenetic mechanisms is crucial…