Recently, we analyzed bivalent chromatin states in cancer. This bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location i.e. promoter or…
In RNA-Sequencing, reads originate from mRNAs or ncRNAs and can span exon junctions. The biological process leading to exon junctions is called splicing. We have extended our alignment software…
Methylated DNA is one of the main epigenetic modifications. We implemented the functionality to map bisulfite sequencing derived reads (Otto et al., 2013) into our alignment software Segemehl…
To identify significantly different methylation levels between certain conditions and among larger numbers of samples, we developed a program called metilene (Juehling et al., 2016). This software…
Hauptausschuss beschließt Maßnahmen gegen Jenaer Alternsforscher Karl Lenhard Rudolph
Die Deutsche Forschungsgemeinschaft (DFG) zieht erneut Konsequenzen aus einem Fall von wissenschaftlichem…
Computational Biology of Aging: The Algorithm of Growing Old
The Computational Biology Group is a young research team. One of our primary interests is to contribute to a better understanding of the…