As proteins misfold and accumulate with age, their removal is essential for maintaining cellular function, especially in postmitotic cells like neurons. The two primary proteolytic systems…
Contact
Jürgen Sühnel Coordinator JenAge +49 3641 65-6200 juergen.suehnel@leibniz-fli.de
Project Period: 01.10.2009 - 30.09.2014
JenAge (BMBF)
Aging and the development of age-related diseases are…
We experimentally track the evolution of immune repertoires and microbes in killifish, a model organism of vertebrate aging. This project develops a predictive approach for the co-evolutionary…
The ability to maintain a functional proteome declines during the aging process, which results in dysregulated protein homeostasis and the accumulation of damaged, misfolded, and partially…
Contact
Lars Björn Riecken Project Leader +49 3641 65-6421 lars.riecken@leibniz-fli.de
More information: www.bmbf.de
NRG1-PRT
Tumors of the nerve sheaths originating from Schwann cells (e.g.…
Contact
Christoph Englert Spokesperson christoph.englert@leibniz-fli.de
For more information about our recent activities, publications and open positions visit…
Biology of aging
Identification of manipulations which lead to life-extension is a milestone towards understanding the biological mechanisms controlling longevity. Due to its short lifespan,…
XpandHSC – functional blood stem cells
XpandHSC: Ex vivo expansion of functional human hematopoietic stem cells to improve therapy
Challenge
One important limiting factor for successful clinical…