Salt could help to boost the immune defense against cancer. This is suggested by the research findings of a team led by Prof. Dr. Christina Zielinski, who holds the Chair of Infection Immunology at…
Spotlight on the FLI Team (6): Jeanne Wilbrandt, Core Facility Life Science Computing
Jena. Careful management and structuring of research data—this is what Dr. Jeanne Wilbrandt is commited to…
Children's Tumor Foundation
The project aims to address Neurofibromatosis type 2 (NF2) by restoring physiological NF2 gene function using CRISPR-based gene editing technology. We seek to permanently…
As proteins misfold and accumulate with age, their removal is essential for maintaining cellular function, especially in postmitotic cells like neurons. The two primary proteolytic systems…
The aim for the current, second funding period is the thorough evaluation of treatment strategies to suppress graft rejection to improve the outcome of clinical pancreatic islet transplantation.
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We experimentally track the evolution of immune repertoires and microbes in killifish, a model organism of vertebrate aging. This project develops a predictive approach for the co-evolutionary…
The liver plays a central role in the pathogenesis of live-threatening sepsis. Cross talk between parenchymal and immune cells, primarily tissue-resident macrophages (Kupffer cells) and…
About 25% of all patients in intensive care suffer from non-curable Critical-Illness-Myopathy (CIM). In sepsis patients, the development of CIM is associated with muscular inflammation. Moreover,…
NRG1-PRT
Tumors of the nerve sheaths originating from Schwann cells (e.g. Schwannomas) are benign, but patients suffer from a variety of different tumors that disrupt the function of the affected…