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Core Facilites and Core Services

At the beginning of 2016, a “core” structure was put into effect that organized facility and service units as independent organizational entities from FLI’s research groups. A number of technology platforms (e.g. sequencing, mass spectrometry) grew out of individual methodological requirements for single research groups in the last years but developed into semiautonomous substructures. As consequence of re-focused research activities and the concomitant advent of new research groups at FLI, those units increasingly had to serve many FLI groups and collaborative research efforts in the Jena research area.

To accommodate this development and to increase efficiency as well as transparency for users, facility personnel and for administrative processes, it came natural to re-organize such activities into independent units as “FLI Core Facilities and Services” and to phase out infrastructures considered non-essential for FLI’s research focus (X-ray crystallography and NMR spectroscopy).

FLI’s Core Facilities (CF) are managed by a CF Manager and are each scientifically guided in their activities and development by an FLI Group Leader, as Scientific Supervisor. The animal facilities comprising fish, mouse and transgenesis are run separately, as they involve a more complex organizational structure. Basic Core Services (CS) are directly led by the Head of Core (HC), who in turn is supported by individual CS Managers.

All facilities and services, including animal facilities, have a valuable contribution to FLI’s research articles; e.g. from 2016–2018, to 54% of all peer reviewed research publications. 

Overview Core Facilities & Services

Overview Core Facilities and Core Services at FLI.

Publications

(since 2016)

2025

  • Analysis of microRNA expression reveals convergent evolution of the molecular control of diapause in annual killifishes.
    Barth* E, Baumgart* M, Dolfi* L, Cui R, Groth M, Ripa R, Savino A, Valenzano DR, Platzer M, Marz** M, Cellerino** A
    Front Genet 2025, 16, 1583989 * equal contribution, ** co-corresponding authors
  • Metabolic modelling reveals the aging-associated decline of host-microbiome metabolic interactions in mice.
    Best L, Dost T, Esser D, Flor S, Gamarra AM, Haase M, Kadibalban AS, Marinos G, Walker A, Zimmermann J, Simon R, Schmidt S, Taubenheim J, Künzel S, Häsler R, Franzenburg S, Groth M, Waschina S, Rosenstiel P, Sommer F, Witte OW, Schmitt-Kopplin P, Baines JF, Frahm C, Kaleta C
    Nat Microbiol 2025, 10(4), 973-91
  • The microcephaly-associated protein YIPF5 differentially regulates ER-export
    Bruno F, Anitei M, Di Fraia D, Durso W, Dau T, Cirri E, Sannai M, Valkova C, Maldutyte J, A.Miller E, Rubio I, Garloff V, Kersten N, Farias G, Ori A, Mestres I, Calegari F, Kaether C
    bioRxiv 2025, https://doi.org/10.1101/2025.06.
  • Translational Remodeling of the Synaptic Proteome During Aging.
    Caterino C, Ugolini M, Durso W, Jevdokimenko K, Groth M, Riege K, Görlach M, Fornasiero E, Ori A, Hoffmann S, Cellerino A
    Aging Cell 2025 (epub ahead of print)
  • The transcriptome of the olm provides insights into its evolution and gene expression.
    Holtze S, Demirtürk D, Ohlenschläger O, Hegele S, Siniuk K, Förste S, Raghavan V, Groth M, Bens M, Hassel N, Martel A, Lukač M, Cizelj I, Fischer M, Liu H, Hildebrandt TB, Hoffmann S, Sahm A
    Sci Rep 2025, 15(1), 28324
  • Oncogenic FLT3 internal tandem duplications (ITD) and CD45/PTPRC control osteoclast functions and bone microarchitecture.
    Lossius-Cott C, Annoh A, Bens M, Nietzsche S, Hoffmann B, Figge MT, Rauner M, Hofbauer LC, Müller JP
    JBMR Plus 2025, 9(3), ziae173
  • Aging and diet alter the protein ubiquitylation landscape in the mouse brain.
    Marino* A, Di Fraia* D, Panfilova D, Sahu AK, Minetti A, Omrani O, Cirri E, Ori A
    Nat Commun 2025, 16(1), 5266 * equal contribution
  • DNA damage response regulator ATR licenses PINK1-mediated mitophagy.
    Marx* C, Qing* X, Gong* Y, Kirkpatrick J, Siniuk K, Beznoussenko GV, Kidiyoor GR, Kirtay M, Buder K, Koch P, Westermann M, Bruhn C, Brown EJ, Xu X, Foiani M, Wang ZQ
    Nucleic Acids Res 2025, 53(5), gkaf178 * equal contribution
  • Analysis of different strains of the turquoise killifish identify transcriptomic signatures associated with heritable lifespan differences.
    Mazzetto M, Reichwald K, Koch P, Groth M, Cellerino A
    J Gerontol A Biol Sci Med Sci 2025, 80(7), glae255
  • Replication stress responses in human lymphocytes change sex-specifically during aging.
    Rall-Scharpf M, Schlotter D, Koch P, Szafranski K, Groth M, Sahm A, Biber S, Castaño BA, Heitmeir B, Zengerling F, Deniz M, Dallmeier D, Braig S, Bonig H, Milyavsky M, Pospiech H, Wiesmüller L
    Nucleic Acids Res 2025, 53(11), gkaf498