The Blueprint of Life
Matthias Platzer has retired as FLI Group Leader in August 2018.
The research group Genome Analysis with its group leader Matthias Platzer lays its focus on genetic and epigenetic aspects of aging. By means of state-of-the-art methods and tools, the information stored in DNA can be read out and the sequence of millions and millions of DNA building blocks may be determined within a short time. We use these methods to describe the genetic information as well as the processes underpinning e.g. the production of proteins and the alterations of these processes during aging.
We work on the functional and comparative analysis of genomes and transcriptomes of short- and long-lived model organisms in aging research. With clinical partners, we search for genetic and epigenetic variations determining the individual predisposition to healthy aging and complex aging-related diseases.
- Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.
Hiller* M, Huse* K, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, Platzer M
Nat Genet 2004, 36(12), 1255-7 * equal contribution
- Finishing the euchromatic sequence of the human genome.
International Human Genome Sequencing Consortium (...), Platzer M, Baumgart C, Förste S, Galgoczy P, Glöckner G, Görlich Y, Heinze I, Jahn N, Lagemann D, Lehmann R, Meier E, Michaelis E, Petz U, Reichwald K, Schilhabel M, Seitz K, Siddiqui R, Taudien S, Wen G, Werler D, (...)
Nature 2004, 431(7011), 931-45