FLI Colloquium with Adam MacLean: Mathematical modeling with single-cell data reveals the states and fates of stem cells


Systems biologist Adam MacLean from the USC Dornsife College of Letters, Arts and Science, University of Southern California (USA), will speak at the FLI on July 29 about modeling the fate decisions of stem cells.


Jena. To enable multicellular life, cells must make decisions regarding their fate. These decisions are fundamental to development and homeostasis and can deteriorate with age.

Genomic data from single cells provide high-resolution insights into the state and fate of cells. “Despite great promise, we have yet to harness these information to understand cell fate decisions in development and aging”, explains MacLean. Additionally, there is limited understanding of how gene regulatory networks control these decisions.

Adam MacLean will present recent work from his research team on modeling cell fate decisions in hematopoietic stem cells. In addition, he will explain how his group has discovered that early-life events (mutation, transcription and epigenetics) can influence the function of stem cells in old age. This knowledge could be used to prevent the onset of age-related diseases.

Information about Adam MacLean:

Title of Talk:Mathematical modeling with single-cell data reveals the states and fates of stem cells
When:Monday, July 29, 2024, 3:00 pm
Where:Seminar room “Nucleus”, main building (FLI 1), Beutenbergstraße 11, Jena
Host:       K. Lenhard Rudolph (Group leader Stem Cell and Metabolism Aging)

The colloquium will be a hybrid event. Details for accessing the session will be provided before the colloquium takes place. For external guests: Please contact Ivonne.Roeppnack-Jahnke@~@leibniz-fli.de for details.