Publikationen

2024

• Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
  Minetti A, Omrani O, Brenner C, Allies G, Imada S, Rösler J, Khawaled S, Cansiz F, W.Meckelmann S, Gebert N, Heinze I, Lu J, Spengler K, Rasa M, Heller R, Yilmaz O, Tasdogan A, Neri F, Ori A
  bioRxiv 2024, https://doi.org/10.1101/2024.07.
  
• Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease.
  Nyame K, Hims A, Aburous A, Laqtom NN, Dong W, Medoh UN, Heiby JC, Xiong J, Ori A, Abu-Remaileh M
  Mol Cell 2024 (epub ahead of print)
  
• iSODA: A Comprehensive Tool for Integrative Omics Data Analysis in Single- and Multi-Omics Experiments
  Olivier-Jimenez D, J.E.Derks R, Harari O, Cruchaga C, Ali M, Ori A, Di Fraia D, Cabukusta B, Henrie A, Giera M, Mohammed Y
  bioRxiv 2024, https://doi.org/10.1101/2024.08.
  
• Remodelling of the cardiac extracellular matrix proteome during chronological and pathological ageing.
  Santinha D, Vilaça A, Estronca L, Schüler SC, Bartoli C, De Sandre-Giovannoli A, Figueiredo A, Quaas M, Pompe T, Ori** A, Ferreira** L
  Mol Cell Proteomics 2024, 23(1), 100706 ** co-corresponding authors
  
• Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
  Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang YJ, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Kargbo-Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colón-Mercado JM, Reyes JF, Ryan VH, Nelson MP, Cook CN, Li Z, Screven L, Kwan JY, Mehta PR, Zanovello M, Hallegger M, Shantaraman A, Ping L, Koike Y, Oskarsson B, Staff NP, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Reich DS, Rohrer JD, Malaspina A, Dickson DW, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME
  Sci Transl Med 2024, 16(734), eadg7162
  
• Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans.
  Sharifi* S, Chaudhari* P, Martirosyan A, Eberhardt AO, Witt F, Gollowitzer A, Lange L, Woitzat Y, Okoli EM, Li H, Rahnis N, Kirkpatrick J, Werz O, Ori A, Koeberle A, Bierhoff** H, Ermolaeva** M
  Nat Commun 2024, 15(1), 1702 * equal contribution, ** co-corresponding authors
  
• The cytoskeletal protein Leiomodin 1 controls Sirtuin 1 localization during myogenic differentiation
  Späth E
  Dissertation 2024, Jena, Germany
  
• Leiomodin 1 promotes myogenic differentiation by modulating Sirtuin 1
  Späth* E, C.Schüler* S, Heinze I, Dau T, Minetti A, Hofmann M, von Maltzahn** J, Ori** A
  bioRxiv 2024, https://doi.org/10.1101/2024.03. * equal contribution, ** co-corresponding authors
  
• Proteomic profiling reveals CEACAM6 function in driving gallbladder cancer aggressiveness through integrin receptor, PRKCD and AKT/ERK signaling.
  Sugiyanto RN, Metzger C, Inal A, Truckenmueller F, Gür K, Eiteneuer E, Huth T, Fraas A, Heinze I, Kirkpatrick J, Sticht C, Albrecht T, Goeppert B, Poth T, Pusch S, Mehrabi A, Schirmacher P, Ji J, Ori A, Roessler S
  Cell Death Dis 2024, 15(10), 780
  
• SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling.
  Weiler SME, Bissinger M, Rose F, von Bubnoff F, Lutz T, Ori A, Schirmacher P, Breuhahn K
  Cancer Lett 2024, 584, 216637