Publikationen

2025

• The microcephaly-associated protein YIPF5 differentially regulates ER-export
  Bruno F, Anitei M, Di Fraia D, Durso W, Dau T, Cirri E, Sannai M, Valkova C, Maldutyte J, A.Miller E, Rubio I, Garloff V, Kersten N, Farias G, Ori A, Mestres I, Calegari F, Kaether C
  bioRxiv 2025, https://doi.org/10.1101/2025.06.
  
• Translational Remodeling of the Synaptic Proteome During Aging.
  Caterino C, Ugolini M, Durso W, Jevdokimenko K, Groth M, Riege K, Görlach M, Fornasiero E, Ori A, Hoffmann S, Cellerino A
  Aging Cell 2025, 24(12), e70262
  
• Altered translation elongation contributes to key hallmarks of aging in the killifish brain.
  Di Fraia* D, Marino* A, Lee* JH, Kelmer Sacramento E, Baumgart M, Bagnoli S, Balla T, Schalk F, Kamrad S, Guan R, Caterino C, Giannuzzi C, Tomaz da Silva P, Sahu AK, Gut H, Siano G, Tiessen M, Terzibasi-Tozzini E, Fornasiero EF, Gagneur J, Englert C, Patil KR, Correia-Melo C, Nedialkova DD, Frydman** J, Cellerino** A, Ori** A
  Science 2025, 389(6759), eadk3079 * equal contribution, ** co-corresponding authors
  
• The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.
  Feringa FM, Koppes-den Hertog SJ, Wang LY, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward ME, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R
  Nat Metab 2025, 7(10), 2142-64
  
• Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin.
  Iqbal S, Andersson S, Nesta E, Pentinmikko N, Kumar A, Kumar Jha S, Borshagovski D, Webb A, Gebert N, Viitala EW, Ritchie A, Scharaw S, Kuuluvainen E, Larsen HL, Saarinen T, Juuti A, Ristimäki A, Jeltsch M, Ori A, Varjosalo M, Pietiläinen KH, Ollila S, Jensen KB, Oudhoff MJ, Katajisto P
  Cell Stem Cell 2025, 32(4), 613-626.e8
  
• Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
  Kumar Sahu A, Minetti A, Di Fraia D, Marino A, Rainer Winterhalter P, Giustarini D, Simm A, Neri F, Galvagni F, Gerhardt C, Pfirrmann** T, Ori** A
  bioRxiv 2025, https://doi.org/10.1101/2025.08. ** co-corresponding authors
  
• Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation
  M.Monteiro L, R.Pitrez P, Correia-Santos S, Dark N, Santinha D, Aveleira C, Townsend M, Taylor J, Nissan X, Sardão V, Cortes L, Mitter R, Marino A, Sousa-Soares C, Ribeiro R, C.Smith J, Logarinho E, Ori A, S.Bernardo A, Ferreira L
  bioRxiv 2025, https://doi.org/10.1101/2025.06.
  
• Aging and diet alter the protein ubiquitylation landscape in the mouse brain.
  Marino* A, Di Fraia* D, Panfilova D, Sahu AK, Minetti A, Omrani O, Cirri E, Ori A
  Nat Commun 2025, 16(1), 5266 * equal contribution
  
• Polyamines support intestinal epithelium regeneration in aging by regulating protein homeostasis
  Minetti A
  Dissertation 2025, Jena, Germany
  
• Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.
  Minetti* A, Omrani* O, Brenner C, Cansiz F, Imada S, Rösler J, Khawaled S, Allies G, Meckelmann SW, Gebert N, Heinze I, Rahnis N, Lu J, Spengler K, Rasa M, Cirri E, Heller R, Yilmaz Ö, Tasdogan A, Neri** F, Ori** A
  Nat Cell Biol 2025 (epub ahead of print) * equal contribution, ** co-senior authors