Ehemalige Forschungsgruppe Than (bis 2015)



  • Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.
    Mishra V, Re DB, Le Verche V, Alvarez MJ, Vasciaveo A, Jacquier A, Doulias PT, Greco TM, Nizzardo M, Papadimitriou D, Nagata T, Rinchetti P, Perez-Torres EJ, Politi KA, Ikiz B, Clare K, Than ME, Corti S, Ischiropoulos H, Lotti F, Califano A, Przedborski S
    Nat Commun 2020, 11(1), 5579


  • Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
    Lam van TV, Ivanova T, Hardes K, Heindl MR, Morty RE, Böttcher-Friebertshäuser E, Lindberg I, Than ME, Dahms SO, Steinmetzer T
    ChemMedChem 2019, 14(6), 673-85


  • X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
    Dahms SO, Hardes K, Steinmetzer T, Than ME
    Biochemistry 2018, 57(6), 925-34


  • Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
    Dahms SO, Jiao** GS, Than** ME
    ACS Chem Biol 2017, 12(5), 1211-6 ** co-corresponding authors
  • Optimization of Substrate-Analogue Furin Inhibitors.
    Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T
    ChemMedChem 2017, 12(23), 1953-68