Forschungsgruppe Kaether



  • Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3.
    Kornak U, Mademan I, Schinke M, Voigt M, Krawitz P, Hecht J, Barvencik F, Schinke T, Gießelmann S, Beil FT, Pou-Serradell A, Vílchez JJ, Beetz C, Deconinck T, Timmerman V, Kaether C, De Jonghe P, Hübner CA, Gal A, Amling M, Mundlos S, Baets J, Kurth I
    Brain 2014, 137(Pt 3), 683-92
  • Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.
    Scherer O, Steinmetz H, Kaether C, Weinigel C, Barz D, Kleinert H, Menche D, Müller R, Pergola C, Werz O
    Biochem Pharmacol 2014, 91(4), 490-500
  • A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer's disease model.
    Wang S, Yu Y, Geng S, Wang D, Zhang L, Xie X, Wu B, Li C, Xu H, Li X, Hu Y, Zhang L, Kaether C, Wang B
    Alzheimers Res Ther 2014, 6(3), 26


  • Small molecules intercept Notch signaling and the early secretory pathway.
    Krämer A, Mentrup T, Kleizen B, Rivera-Milla E, Reichenbach D, Enzensperger C, Nohl R, Täuscher E, Görls H, Ploubidou A, Englert C, Werz O, Arndt HD, Kaether C
    Nat Chem Biol 2013, 9, 731–8


  • Trafficking and proteolytic processing of APP.
    Haass C, Kaether C, Thinakaran G, Sisodia S
    Cold Spring Harb Perspect Med 2012, 2(5), a006270
  • Accumulation of annexin A5 at the nuclear envelope is a biomarker of cellular aging.
    Klement K, Melle C, Murzik U, Diekmann S, Norgauer J, Hemmerich P
    Mech Ageing Dev 2012, 133(7), 508-22
  • Identification of novel regulators of notch signaling by image based screening
    Krämer AM
    Dissertation 2012, Jena, Germany
  • Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons.
    Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J
    J Neurosci 2012, 32(2), 738-45


  • Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.
    Fassler M, Li X, Kaether C
    J Biol Chem 2011, 286(44), 38390-6
  • Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death.
    Juenemann K, Weisse C, Reichmann D, Kaether C, Calkhoven CF, Schilling G
    Neurotox Res 2011, 20(2), 120-33