Heidel Associated Research Group

Stem Cell Aging/
Myeloid Neoplasia

The research group of Florian H. Heidel is associated to the FLI as a cooperation group between the University Hospital Jena (UKJ) and the FLI – located at the UKJ. The group is funded by the Federal Programme “ProExzellenz II” of the Free State of Thuringia.

The group's research interest is the development of myeloid neoplasia during aging of the hematopoietic system. The researchers employ genetically engineered mouse models and RNAi technology to functionally characterize signaling pathways and molecules involved in self-renewal, differentiation and aging of hematopoietic stem cells. Moreover, they aim to identify novel therapeutic targets for clinical therapy of aging associated myeloid cancers.

Plcg1 signaling is activated in hematopoietic stem- and progenitor cells but inactive in differentiated myeloid progeny.
Plcg1 signaling

Contact

Prof. Dr. Florian H. Heidel

Florian H. Heidel
Associated Group Leader
florian.heidel@leibniz-fli.de

Ramona Kraft
Secretary (UKJ)
+49 (0)3641-9324210