Welcome to the Leibniz Institute on Aging (FLI)
The Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) is the first national research institute in Germany focusing on biomedical research on human aging, a multifactorial process controlled by environmental and genetic factors.
This website will provide you with an insight into our institute, the research we do and the faces behind FLI's science activities. We wish you an exciting and entertaining voyage of discovery into the world of aging research at FLI.
Since 2004, our mission has been to delineate basic molecular mechanisms that underlie the aging process in humans and its consequences for the development of aging-related cell and tissue dysfunction and diseases. Research at the FLI will provide a knowledge basis for the development of therapies aiming to facilitate healthy aging by prolonging organismal functions and disease prevention in the elderly.
In order to better correspond to this research focus, the institute was re-named from Leibniz Institute for Age Research into Leibniz Institute on Aging in 2015.
recent high impact publications
- Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation.
Avila AI, Illing A, Becker F, Maerz LD, Morita Y, Philipp M, Burkhalter MD
Nucleic Acids Res 2016 (epub ahead of print)
- Polymorphism of Amyloid Fibrils In Vivo.
Annamalai K, Gührs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Schönland S, Fändrich M
Angew Chem Int Ed Engl 2016, 55(15), 4822-5
- High Copy Numbers of Beta-Defensin Cluster on 8p23.1 Confer Genetic Susceptibility and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa.
Giamarellos-Bourboulis* EJ, Platzer* M, Karagiannidis* I, Kanni T, Nikolakis G, Ulrich J, Bellutti M, Gollnick H, Bauer M, Zouboulis CC, Huse K
J Invest Dermatol 2016 (epub ahead of print) * equal contribution
- You Are What You Eat: Linking High-Fat Diet to Stem Cell Dysfunction and Tumorigenesis.
Haller S, Jasper H
Cell Stem Cell 2016, 18(5), 564-6
- Automated structure modeling of large protein assemblies using crosslinks as distance restraints.
Ferber M, Kosinski J, Ori A, Rashid UJ, Moreno-Morcillo M, Simon B, Bouvier G, Batista PR, Müller CW, Beck M, Nilges M
Nat Methods 2016 (epub ahead of print) published during change of institution
- Spatiotemporal variation of mammalian protein complex stoichiometries.
Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andrés-Pons A, Singer S, Bork P, Beck M
Genome Biol 2016, 17(1), 47