Welcome to the Leibniz Institute on Aging (FLI)
The Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) is the first national research institute in Germany focusing on biomedical research on human aging, a multifactorial process controlled by environmental and genetic factors.
This website will provide you with an insight into our institute, the research we do and the faces behind FLI's science activities. We wish you an exciting and entertaining voyage of discovery into the world of aging research at FLI.
Since 2004, our mission has been to delineate basic molecular mechanisms that underlie the aging process in humans and its consequences for the development of aging-related cell and tissue dysfunction and diseases. Research at the FLI will provide a knowledge basis for the development of therapies aiming to facilitate healthy aging by prolonging organismal functions and disease prevention in the elderly.
In order to better correspond to this research focus, the institute was re-named from Leibniz Institute for Age Research to the Leibniz Institute on Aging in 2015.
recent high impact publications
- MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging.
Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, Groth M, Terzibasi Tozzini E, Baumgart M, Cellerino A
BMC Biol 2017, 15(1), 9
- Gain of function in Jak2(V617F)-positive T-cells.
Nishanth G, Wolleschak D, Fahldieck C, Fischer T, Mullally A, Perner F, Schnöder TM, Just S, Heidel* FH, Schlüter* D
Leukemia 2017 (epub ahead of print) * equal contribution
- RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts.
Gieseler-Halbach S, Meltendorf S, Pierau M, Weinert S, Heidel FH, Fischer T, Handschuh J, Braun-Dullaeus RC, Schrappe M, Lindquist JA, Mertens PR, Thomas U, Brunner-Weinzierl MC
Cell Death Differ 2017, 24(2), 371-83
- Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.
Neves J, Sousa-Victor P, Jasper H
Cell Stem Cell 2017, 20(2), 161-75
- Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity.
Mindos T, Dun XP, North K, Doddrell RDS, Schulz A, Edwards P, Russell J, Gray B, Roberts SL, Shivane A, Mortimer G, Pirie M, Zhang N, Pan D, Morrison H, Parkinson DB
J Cell Biol 2017 (epub ahead of print)
- Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.
Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C
Proc Natl Acad Sci U S A 2017 (epub ahead of print)