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Welcome to the Leibniz Institute on Aging (FLI)

The Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) is the first national research institute in Germany focusing on biomedical research on human aging, a multifactorial process controlled by environmental and genetic factors.

This website will provide you with an insight into our institute, the research we do and the faces behind FLI's science activities. We wish you an exciting and entertaining voyage of discovery into the world of aging research at FLI.



Since 2004, our mission has been to delineate basic molecular mechanisms that underlie the aging process in humans and its consequences for the development of aging-related cell and tissue dysfunction and diseases. Research at the FLI will provide a knowledge basis for the development of therapies aiming to facilitate healthy aging by prolonging organismal functions and disease prevention in the elderly.

In order to better correspond to this research focus, the institute was re-named from Leibniz Institute for Age Research into Leibniz Institute on Aging in 2015.

recent high impact publications

  • Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
    Dahms* SO, Arciniega* M, Steinmetzer T, Huber** R, Than** ME
    Proc Natl Acad Sci U S A 2016 (epub ahead of print) * equal contribution, ** co-corresponding authors
  • Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.
    Taudien* S, Lausser* L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler** HA, Platzer** M
    EBioMedicine 2016 (epub ahead of print) * equal contribution, ** co-senior authors
  • Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.
    Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AVS, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM
    EBioMedicine 2016 (epub ahead of print)
  • Age-Dependent Changes of Monocarboxylate Transporter 8 Availability in the Postnatal Murine Retina
    Yoshiyuki H, Szafranski K
    Front Cell Neurosci 2016, http://dx.doi.org/10.3389/fncel.
  • Impaired planar germ cell division in the testis, caused by dissociation of RHAMM from the spindle, results in hypofertility and seminoma.
    Li H, Frappart* L, Moll* J, Winkler* A, Kroll T, Hamann J, Kufferath I, Groth M, Taudien S, Schütte M, Yaspo ML, Heuer H, Lange BMH, Platzer M, Zatloukal K, Herrlich P, Ploubidou A
    Cancer Res 2016 (epub ahead of print) * equal contribution
  • Multifocal Nerve Lesions and LZTR1 Germline Mutations in Segmental Schwannomatosis.
    Farschtschi S, Mautner VF, Pham M, Nguyen R, Kehrer-Sawatzki H, Hutter S, Friedrich RE, Schulz A, Morrison H, Jones DTW, Bendszus M, Bäumer P
    Ann Neurol 2016 (epub ahead of print)

Recent FLI Press Releases

Wissenschaftler aus Jena und Ulm untersuchten den Zusammenhang zwischen den Genen von Sepsispatienten und der Schwere des Krankheitsverlaufes.

Forscher an der Klinik für Frauenheilkunde und Geburtshilfe der Universität Ulm haben einen Mechanismus entdeckt, der erklären könnte, warum sich...

Dass der menschliche Körper komplex ist, haben wir immer geahnt. Dass Schilddrüsenhormone das Farbsehen beeinflussen, überrascht dennoch. Genau dieses...

Prof. Bernhard Müller, Direktor des Leibniz-Instituts für ökologische Raumentwicklung (IÖR) und Professor für Raumentwicklung der TU Dresden, spricht...

Why do cells and tissues age and what are the genetic and molecular causes for aging? These are the central research questions that Italian junior...