Welcome to the Leibniz Institute on Aging (FLI)
The Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) is the first national research institute in Germany focusing on biomedical research on human aging, a multifactorial process controlled by environmental and genetic factors.
This website will provide you with an insight into our institute, the research we do and the faces behind FLI's science activities. We wish you an exciting and entertaining voyage of discovery into the world of aging research at FLI.
Since 2004, our mission has been to delineate basic molecular mechanisms that underlie the aging process in humans and its consequences for the development of aging-related cell and tissue dysfunction and diseases. Research at the FLI will provide a knowledge basis for the development of therapies aiming to facilitate healthy aging by prolonging organismal functions and disease prevention in the elderly.
In order to better correspond to this research focus, the institute was re-named from Leibniz Institute for Age Research into Leibniz Institute on Aging in 2015.
recent high impact publications
- Automated structure modeling of large protein assemblies using crosslinks as distance restraints.
Ferber M, Kosinski J, Ori A, Rashid UJ, Moreno-Morcillo M, Simon B, Bouvier G, Batista PR, Müller CW, Beck M, Nilges M
Nat Methods 2016 (epub ahead of print) published during change of institution
- Spatiotemporal variation of mammalian protein complex stoichiometries.
Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andrés-Pons A, Singer S, Bork P, Beck M
Genome Biol 2016, 17(1), 47
- Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice.
Seeling M, Hillenhoff U, David JP, Schett G, Tuckermann J, Lux A, Nimmerjahn F
Proc Natl Acad Sci U S A 2013, 110(26), 10729-34 published during change of institution
- Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.
Adams* PD, Jasper* H, Rudolph* KL
Cell Stem Cell 2015, 16(6), 601-12 ** co-corresponding authors
- Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.
Wang J, Morita Y, Han B, Niemann S, Löffler B, Rudolph KL
Nat Cell Biol 2016 (epub ahead of print) recommended by "Faculty of 1000" - Prime
- SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.
Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu G, Li T, Ju Z
Cell Stem Cell 2016, 18(4), 495-507