Welcome to the Leibniz Institute on Aging (FLI)
The Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) is the first national research institute in Germany focusing on biomedical research on human aging, a multifactorial process controlled by environmental and genetic factors.
This website will provide you with an insight into our institute, the research we do and the faces behind FLI's science activities. We wish you an exciting and entertaining voyage of discovery into the world of aging research at FLI.
Since 2004, our mission has been to delineate basic molecular mechanisms that underlie the aging process in humans and its consequences for the development of aging-related cell and tissue dysfunction and diseases. Research at the FLI will provide a knowledge basis for the development of therapies aiming to facilitate healthy aging by prolonging organismal functions and disease prevention in the elderly.
In order to better correspond to this research focus, the institute was re-named from Leibniz Institute for Age Research into Leibniz Institute on Aging in 2015.
recent high impact publications
- Shwachman-Bodian-Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mRNAs.
In K, Zaini MA, Müller C, Warren AJ, von Lindern M, Calkhoven CF
Nucleic Acids Res 2016 (epub ahead of print)
- What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch.
Duchardt-Ferner E, Gottstein-Schmidtke SR, Weigand JE, Ohlenschläger O, Wurm JP, Hammann C, Suess B, Wöhnert J
Angew Chem Int Ed Engl 2016, 55(4), 1527-30
- Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
Obermeier K, Sachsenweger J, Friedl TWP, Pospiech H, Winqvist R, Wiesmüller L
Oncogene 2016 (epub ahead of print)
- Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
Reichwald* K, Petzold* A, Koch* P, Downie* BR, Hartmann* N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Görlach M, Than ME, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino** A, Englert** C, Platzer** M
Cell 2015, 163(6), 1527-38 * equal contribution, ** co-senior authors, featured in Nature News by Ewen Callaway: Short-lived fish may hold clues to human ageing. Nature 2015 528(7581):175
- Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.
Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte OW, Zarse K, Ristow M
Nat Commun 2015, 6, 10043
- Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division.
Dumont NA, Wang YX, von Maltzahn J, Pasut A, Bentzinger CF, Brun CE, Rudnicki MA
Nat Med 2015, 21(12), 1455-63