FLI Colloquium with Larry S. Sherman: Contributions of hyaluronan catabolism to cognitive dysfunction in aging and neuroinflammatory diseases

Seminars

On August 24, neuroscientist Prof Larry S. Sherman of the Oregon National primate research center will give a talk on the role of hyaluronan catabolism in normal and pathological aging of the brain.

The Sherman lab has found that the glycosaminoglycan hyaluronan (HA) accumulates throughout the brain with normative aging, a process that is accelerated in cases of age-related vascular brain injury and dementia.

Dysregulated HA signaling through the CD44 transmembrane HA receptor leads to cognitive dysfunction, altered neurogenesis, and a persistent neuroinflammatory response involving changes in brain vascular endothelial cells.

The talk will highlight how each targeted approaches to treating age-related cognitive decline can be implemented with respect to both of these processes.

Larry S. Sherman is Professor at the Oregon National Primate Research Center at Oregon Health & Science University, Beaverton, USA. The Sherman lab focuses, among other things, on how neuronal cell differentiation is regulated and how these cells can be influenced to promote recovery from neurodegenerative diseases.


Title of Talk:Contributions of hyaluronan catabolism to cognitive dysfunction in aging and neuroinflammatory diseases
When:Thursday, August 24, 2023, 3:00 pm
Where:Seminar room “Nucleus”, main building (FLI 1), Beutenbergstraße 11, Jena
Host:       Helen Morrison (Group leader: Nerve Regeneration)

The colloquium will be a hybrid event. Details for accessing the session will be provided before the colloquium takes place. For external guests: Please contact Ivonne.Roeppnack-Jahnke@~@leibniz-fli.de for details.