Subarea 4: Cell Dynamics and Molecular Damages in Aging
The research focus of Subarea 4 is on studying damages of macromolecules (proteins, nucleic acids) and determining the structure-function relationship of biomolecules relevant to damage and damage repair processes and responses to molecular damage that might lead to aging and aging-associated pathologies.
The studies are focused on the following research areas: DNA replication, DNA damage responses (DDR), stress responses, metabolic stresses, protein trafficking and protein damages.
The research is defined by four focus areas:
- DNA damage response in tissue homeostasis and neuropathies,
- Quality control in the endoplasmic reticulum for secretory pathway in aging processes,
- Intrinsic and extrinsic factors implicated in cellular decline during aging, and
- DNA replication and genomic integrity preventing premature aging and diseases.
Research focus of Subarea 4.
The accumulation of damaged macromolecules or subcellular organelles is associated with dysfunction of a cell, which contributes to tissue & organ failure. DNA damage, genomic instability, protein misfolding or defects in toxic protein degradation can compromise cell functionality. Alterations of mitochondrial DNA and protein complexes affect cellular metabolism, which will have a general impact on cell integrity.
Publications
(since 2016)
2021
- Post-Translational Modification of MRE11: Its Implication in DDR and Diseases.
Lu R, Zhang H, Jiang YN, Wang ZQ, Sun L, Zhou ZW
Genes (Basel) 2021, 12(8) - An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness.
Marfil-Sánchez A, Zhang L, Alonso-Pernas P, Mirhakkak M, Mueller M, Seelbinder B, Ni Y, Santhanam R, Busch A, Beemelmanns C, Ermolaeva** M, Bauer** M, Panagiotou** G
Gut Microbes 2021, 13(1), 1993598 ** co-corresponding authors - Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing's sarcoma cells
Marx C, Schaarschmidt MU, Kirkpatrick J, Marx-Blümel L, Halilovic M, Westermann M, Hoelzer D, Meyer FB, Geng Y, Buder K, Schadwinkel HM, Siniuk K, Becker S, Thierbach R, Beck JF, Sonnemann* J, Wang* ZQ
Cell Biosci 2021, 11(1), 57 * equal contribution - Mechanistic insights into p53-regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells.
Marx C, Sonnemann J, Beyer M, Maddocks ODK, Lilla S, Hauzenberger I, Piée-Staffa A, Siniuk K, Nunna S, Marx-Blümel L, Westermann M, Wagner T, Meyer FB, Thierbach R, Mullins CS, Kdimati S, Linnebacher M, Neri F, Heinzel T, Wang ZQ, Krämer OH
MOL ONCOL 2021, 15(12), 3404-29 - Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.
Marx-Blümel* L, Marx* C, Sonnemann J, Weise F, Hampl J, Frey J, Rothenburger L, Cirri E, Rahnis N, Koch P, Groth M, Schober A, Wang ZQ, Beck JF
Sci Rep 2021, 11(1), 21163 * equal contribution - Butyrate and Metformin Affect Energy Metabolism Independently of the Metabolic Phenotype in the Tumor Therapy Model.
Meyer FB, Marx C, Spangel SB, Thierbach R
Biomolecules 2021, 11(12), 1831 - Silicon-rhodamine isothiocyanate for fluorescent labelling.
Nasufović V, Then P, Dröge F, Duong M, Kaether C, Dietzek B, Heintzmann R, Arndt HD
Org Biomol Chem 2021, 19(3), 574-8 - The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation.
Norizadeh Abbariki T, Gonda Z, Kemler D, Urbanek P, Wagner T, Litfin M, Wang ZQ, Herrlich P, Kassel O
Sci Rep 2021, 11(1), 12904 - Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism.
Shi R, Hou W, Wang ZQ, Xu X
Front Cell Dev Biol 2021, 9, 735678 - COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers
Shomron O, Nevo-Yassaf I, Aviad T, Yaffe Y, Erez Zahavi E, Dukhovny A, Perlson E, Brodsky I, Yeheskel A, Pasmanik-Chor M, Mironov A, Beznoussenko GV, Mironov AA, Sklan EH, Patterson GH, Yonemura Y, Sannai M, Kaether** C, Hirschberg** K
J Cell Biol 2021, 220(6), e201907224 ** co-corresponding authors
