Outstanding Questions

By examining the metabolic microenvironments that emerge from cell-cell metabolite exchange interactions in both healthy and disease-associated aging, we hope to answer outstanding questions in the field:

• How do metabolites secreted by cells alter the physiology of neighboring cells?
• How does this impact aging, disease initiation, and progression?
• How do host and microbiome cells interact metabolically?
• How do clinically used therapeutics affect the metabolic environment?
• How does the metabolic environment influences the efficacy of therapeutical drugs?
• Can we target metabolic pathways or use metabolic adjuvants to aid therapy efficiency?