State-of-the-art Analyses
Our lab aims at building a systems-scale mechanistic understanding of the metabolic microenvironments that modulate health, disease, and response to therapy, with a special focus on aging. For this we integrate high-throughput robotic platforms for culture and phenotyping of both mammalian and microbial cells with mass spectrometry (MS)-based metabolomics and proteomics and systems biology approaches.
The lab focuses on three major areas:
- Host-microbiome metabolic crosstalk during aging.
- Metabolic microenvironment as a driver of disease initiation and progression.
- Metabolic microenvironment generated by therapy-induced senescent cells (TIS cells) as a factor in disease persistence.
Discoveries at all three levels have the potential to translate into interventions that support better health through innovative metabolism-targeting or metabolism-aided therapies.
