Ori Research Group
Aging of Protein Complexes:
The Building Blocks of Our Body
The Research Group “Aging of Protein Complexes” is interested in studying how age and environmental factors affect our organs at the molecular level. The group employs ultra-sensitive approaches allowing the quantification of thousands of proteins in tissues as well as in rare cell populations. The group’s goal is to identify, in an unbiased way, functionally relevant alterations of the proteome that will enable the researchers to understand the mechanisms of organ deterioration that impact on healthy lifespan.
- NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
Wyant* GA, Abu-Remaileh* M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori** A, Sabatini** DM
Science 2018, 360(6390), 751-8 * equal contribution, ** co-corresponding authors
- Landscape of nuclear transport receptor cargo specificity.
Mackmull MT, Klaus B, Heinze I, Chokkalingam M, Beyer A, Russell RB, Ori** A, Beck** M
Mol Syst Biol 2017, 13(12), 962 ** co-corresponding authors, highlighted in the “Principle of Systems Biology” - Cell Systems 6 - 2018
- Spatiotemporal variation of mammalian protein complex stoichiometries.
Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andrés-Pons A, Singer S, Bork P, Beck M
Genome Biol 2016, 17(1), 47 featured in Research Highlights
- Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
Ori* A, Toyama* BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M
Cell Syst 2015, 1(3), 224–237 * equal contribution, published during change of institution
- Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.
Ori A, Banterle N, Iskar M, Andrés-Pons A, Escher C, Bui KH, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M
Mol Syst Biol 2013, 9, 648