Molecular and Cellular Aging

Unlocking the Fundamental Mechanisms of Aging

The Molecular and Cellular Aging program area focuses on deciphering the core biological mechanisms that drive aging at the molecular and cellular levels.

We investigate how aging impacts the maintenance of the proteome and genome, RNA-protein interactions, organelle function, and the mechanisms of molecular damage and repair that sustain tissue and organ homeostasis.

Understanding these foundational processes is crucial for identifying potential interventions to slow or reverse age-related decline.

Key Research Themes:

Genome and Proteome Stability: Investigating the role of DNA damage, genomic instability, and protein misfolding in aging.
RNA Biology & Aging: Exploring the role of non-coding RNAs and other RNA-related processes in aging.
Organelle Dynamics: Studying the function and dysfunction of organelles (e.g., mitochondria, lysosomes) and their impact on cellular health and aging.
Molecular Damage & Repair: Uncovering the mechanisms that protect against molecular damage and the decline of repair mechanisms with age.
Cellular Homeostasis & Senescence: Investigating how cells maintain their function over time, including the roles of cellular stress responses, autophagy, and cellular senescence.
Microbial-Borne Molecules & Aging: Examining the influence of metabolites and other molecules produced by the microbiome on aging processes.

Our Approach:

This program area employs cutting-edge techniques in molecular biology, cell biology, biochemistry, and genetics to dissect the molecular and cellular underpinnings of aging.

We aim to identify novel therapeutic targets and develop strategies to improve cellular function and extend healthspan.