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  • Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in HPA stress axis.
    Sahm* A, Platzer M, Koch P, Henning Y, Bens M, Groth M, Burda H, Begall S, Ting S, Goetz M, Van Daele P, Staniszewska M, Klose J, Costa PF, Hoffmann** S, Szafranski** K, Dammann** P
    Elife 2021, 10, e57843 ** co-senior authors, * corresponding author
  • The analysis of epigenomic evolution
    Sahm** A, Koch P, Horvath S, Hoffmann** S
    bioRxiv 2021 ** co-corresponding authors
  • Aging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice.
    Schädel P, Troisi F, Czapka A, Gebert N, Pace S, Ori A, Werz O
    FASEB J 2021, 35(5), e21558
  • NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships.
    Schmitz T, Paul George AA, Nubbemeyer B, Bäuml CA, Steinmetzer T, Ohlenschläger O, Biswas A, Imhof D
    Int J Mol Sci 2021, 22(2)
  • COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers
    Shomron O, Nevo-Yassaf I, Aviad T, Yaffe Y, Erez Zahavi E, Dukhovny A, Perlson E, Brodsky I, Yeheskel A, Pasmanik-Chor M, Mironov A, Beznoussenko GV, Mironov AA, Sklan EH, Patterson GH, Yonemura Y, Sannai M, Kaether** C, Hirschberg** K
    J Cell Biol 2021, 220(6), e201907224 ** co-corresponding authors
  • Tissue-specific Gene Expression Changes Are Associated with Aging in Mice.
    Srivastava* A, Barth* E, Ermolaeva MA, Guenther M, Frahm C, Marz** M, Witte** OW
    Genomics Proteomics Bioinformatics 2021 (epub ahead of print) * equal contribution, ** co-corresponding authors
  • A comprehensive transcriptome signature of murine hematopoietic stem cell aging.
    Svendsen AF, Yang D, Kim KM, Lazare SS, Skinder N, Zwart E, Mura-Meszaros A, Ausema A, Eyss Bv, de Haan G, Bystrykh LV
    Blood 2021 (epub ahead of print)
  • Correction: Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
    Tang D, Tao S, Chen Z, Koliesnik IO, Calmes PG, Hoerr V, Han B, Gebert N, Zörnig M, Löffler B, Morita Y, Rudolph KL
    J Exp Med 2021, 218(1)
  • HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration.
    Tapias* A, Lázaro* D, Yin* BK, Rasa SMM, Krepelova A, Kelmer Sacramento E, Grigaravicius P, Koch P, Kirkpatrick J, Ori A, Neri F, Wang ZQ
    Elife 2021, 10, e61531 * equal contribution
  • Loss of hepatic Mboat7 leads to liver fibrosis.
    Thangapandi VR, Knittelfelder O, Brosch M, Patsenker E, Vvedenskaya O, Buch S, Hinz S, Hendricks A, Nati M, Herrmann A, Rekhade DR, Berg T, Matz-Soja M, Huse K, Klipp E, Pauling JK, Wodke JA, Miranda Ackerman J, Bonin Mv, Aigner E, Datz C, von Schönfels W, Nehring S, Zeissig S, Röcken C, Dahl A, Chavakis T, Stickel F, Shevchenko A, Schafmayer C, Hampe J, Subramanian P
    Gut 2021, 70(5), 940-50