Information on corona pandemic

The SARS coronavirus-2 (SARS-Cov-2) pandemic is currently showing a low infection rate in Europe and Germany, but local outbreaks occur and we have to stay alerted. Infections in the total population of Germany are below 500 per day and in Jena city of 100,000 citizens, there were 6 new infections in the last 2 months. We decided at this point in time together with FLI directors to continue the planning for the JAM2020 in Jena to be conducted under the most careful conditions and hygiene rules in September 2020.

We encourage you to apply for the scientific program until the closing date, August 9th 2020. We have an outstanding list of speakers discussing new, unpublished results and novel concepts in the aging field. The goal of the JAM2020 is to foster scientific advance in the aging field, which may also help us understand the vulnerability of the aged organism to infections, such as COVID-19.

We ensure you that the safety of our speakers and attendees is of utmost importance to us. The meeting will be conducted according to the actual guidelines on physical distancing and hygiene rules.

Due to the special situation, we have to limit the meeting to a maximum of 95 attendees. The meeting will take place in three lecture halls to guarantee social distancing. These will be connected via live streaming for talks and discussions. There will be ample opportunity to interact with speakers and other participants during coffee breaks, lunches and dinners that will be held in large open-air pavilions to ensure best possible infection prevention with keeping of distancing rules and outside air ventilation. Registrations will be granted on a first comes first serve basis. At this point in time (July 23rd) we have 40 seats left.

According to our regulations at the meeting, all participants will have to be tested on the 16th of September (the evening before the meeting) to ensure that none of our participants carries the virus. This means that everybody (also the speakers) have to be there on the afternoon before the meeting between 2-6 pm. We have arranged for the testing and will give time slots for all participants. The costs for the testing are covered by the registration fee. On this first afternoon/evening you should not plan for any social activities with other meeting attendees but we would just invite you for a time slot to register and for taking another swap for the COVID-test. This is to avoid contacts among participants before the test results are in. On the next day at 2 pm we would start the meeting with all test results being in. This on site testing does not replace the test and health certificate from 48h before your arrival in Germany, which you may need if you travel from risk areas (see information below).

We have to advise all our participants to book only fully refundable tickets and hotel accommodation as a second wave of COVID-19 infection could lead to a late cancellation of the whole meeting. In case of a positive COVID-19 test of a participant, he/she is not allowed to join the meeting. In both scenarios, we would fully refund registration fees, but FLI and the organizers cannot take any liability or reimbursement for financial losses in regard to travel/hotel arrangements.

It may also be possible that some speakers might not be able to attend the conference in person due to travel restrictions in their respective countries, we will then aim to live stream these scientific presentations and to have the affected speakers being present via streaming throughout the meeting also for individual conversations.

July 2020, The organizers


Description

Aging is a major risk factor for the development of organ dysfunction and disease. Although under debate, there exists a strong association between decline in stem cell function, possibly impinging on the selection of mutant stem cells, impairments in tissue maintenance and disease development during aging. The JAM will discuss basic concepts and therapeutic targets on the causes and consequences of stem cell during organism aging.

Principal themes and objectives of the meeting

The JAM fosters interaction of researchers engaged in the study of basic principles of stem cell and tissue maintenance in aging. The meeting will focus on basic molecular and genetic processes that affect genetic and epigenetic stability, protein homeostasis and metabolic processes - thereby impairing the functionality and self-renewal of stem cells and organ maintenance.

The main aim of the JAM is to increase our understanding of organism aging.

Sessions

  • Mitochondria and Protein Homeostasis
  • Systemic and Niche Factors
  • Epigenetics, DNA Damage, Genome Integrity
  • Stem Cells and Regeneration
  • Interventions

Keynote Speakers

Andrew Dillin, University of California, Berkeley, USA

His lab focuses on why an aging organism loses control over the integrity of its proteome with the aim to uncover new therapeutic strategies for the treatment of age-related pathologies.

Vera Gorbunova, University of Rochester, Department of Biology, Rochester, USA

Her lab focuses on the role of Sirtuin signaling in Aging. She works on long-lived rodents and cross species gene replacements to identify longevity mechanisms.

Manuel Serrano, Institute for Research in Biomedicine, Barcelona, Spain

His lab focuses on the role of epigenetic reprogramming in tissue regeneration and on the development of strategies for the elimination of senescent cells in order to prevent cancer growth and tissue destruction.

Speakers

Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Her lab focuses on the innate immune system and has contributed fundamental discoveries in elucidating the mechanisms of immunorecognition of DNA by the cGAS-signaling pathway.

Anne Bertolotti, MRC Laboratory of Molecular Biology, Cambridge, UK

Her lab focuses on mechanisms that govern the deposition of misfolding-prone proteins and their accumulation in aged cells with the aim to identify strategies that could reduce the burden of misfolded proteins for cells and organisms.

Paul Frenette, Albert Einstein College of Medicine, New York, USA

His lab focuses on how hematopoietic stem cells (HSCs) and mature blood cells traffic in vivo. He has uncovered a key role for the peripheral nervous system in the HSC niche regulating HSC trafficking and identified nerve aging as a contributing factor to HSC aging.

David J. Glass, Novartis, Basel, Switzerland

He provided groundbreaking work on the role of metabolic pathways in driving the functional decline of muscle stem cells during aging.

Florian Heidel, Jena University Hospital, Jena, Germany

He works on hematopoietic stem cell aging, especially on the question how this leads to the selection of aberrant stem cell clones and leukemia formation.

Heinrich Jasper, The Buck Institute for Research on Aging, San Francisco, USA

His lab focuses on stress and inflammatory pathways that influence tissue homeostasis and has contributed fundamental discoveries on how age-related dysfunction of somatic stem cells perturbs regeneration in barrier epithelia.

Pankaj Kapahi, The Buck Institute for Research on Aging, San Francisco, USA

He investigates how organisms respond to nutrient status and how this influences health and disease. His lab uses different model organisms to investigate how various physiological and molecular processes, including fat metabolism, circadian clocks, advanced glycation end products, calcification, and intestinal permeability, are influenced by nutrients to impact organismal health and survival.

Pekka Katajisto, University of Helsinki, Helsinki, Finland

His lab studies how stem cell intrinsic and extrinsic mechanisms alter tissue renewal capacity in aging with particular focuses on the intestinal stem cells niche and the interplay between cellular metabolism and stem cell fate.

James L. Kirkland, Mayo Clinic, Rochester, USA

His lab focuses on the impact of cellular aging (senescence) on age-related dysfunction and chronic diseases, with the aim of developing therapies for removing these cells and alleviating their effects.

William Lowry, University of California, Los Angeles, USA

He investigates metabolic control of skin stem cells and how these circuits can affect hair growth and skin stem cell maintenance and function during aging.

Emi Nishimura, Tokyo Medical and Dental University, Tokyo, Japan

She has developed new insides into delineating different lineages of skin stem cells and the role of quiescence in regulating the sensitivity of skin stem cells to DNA damage. Her work provided the first experimental evidence that DNA damage can lead to removal of melanocyte stem cells by inducing differentiation.

Thomas Rando, Stanford University, San Francisco, USA

He is a pioneer of research on muscle stem cell aging. He identified experimental evidence for systemic acting factors in blood circulation that influence aging in heterochronic parabiosis in mice.

Michael Ristow, ETH Zürich, Zürich, Switzerland

He has provided groundbreaking work on the role of oxidative stress in triggering hormesis response that elongate survival in C. elegans.

Hans-Willem Snoeck, Columbia University, New York, USA

His work provides experimental evidence for a novel role of mitochondria in regulating Calcium homeostasis in hematopoietic stem cells.

Aleksandra Trifunovic, CECAD Research Center, Cologne, Germany

Her lab studies the role of mitochondria in the determination of longevity with a particular focus on the impact of accumulation of mutations in mitochondrial DNA.

Claudia Waskow, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany

Her lab has a long-standing interest in developing humanized mouse models to study the biology of human hematopoietic stem cell aging in an experimental in vivo system. She has identified new mechanisms of lineage development in hematopoietic system during embryogenesis.

There is currently no quarantine needed for people coming to Jena from many countries, especially from within Europe. For all travelers from abroad we recommend to inform yourself if the country you are coming from is defined as “risk area” by the Robert Koch Institute, a German federal government agency.

Travelers from risk-areas have to provide a certified medical test stating a negative test result for COVID19 and that no symptoms of Corona-infection are present. This certificate has to be certified translated into German and has to be stating a test result from <48h prior to arrival.

Please check this regularly updated list of risk areas: https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Risikogebiete_neu.html

We will keep you updated on the regulations including the rules on travel inside Germany. For travelers from abroad please enquire with your local state authorities to ensure your travel options.

  • Registration closes on August 9: 300€ (plus possible bank fees)
     
  • Industry Fee: 450€ (plus possible bank fees)

Payment information will be sent separately. We will only ask you to pay the registration fee after August 10th. We will fully refund registration fees in case of a cancellation of the conference.

We have to advise all our participants to book only fully refundable tickets and hotel accommodation as a second wave of COVID-19 infection could lead to a late cancellation of the whole meeting. In case of a positive COVID-19 test of a participant, he/she is not allowed to join the meeting. In both scenarios, we would fully refund registration fees, but FLI and the organizers cannot take any liability or reimbursement for financial losses in regard to travel/hotel arrangements.

The following hotels are situated in the city center of Jena with good connections to public transport to reach the conference venue:

  • IBIS Jena City Hotel, 76€/night incl. breakfast, 20 rooms reserved until August 17 (We reserved a contingent of hotel rooms here, keyword "Jena Aging Meeting")
  • Eulensteins, 70€/night incl. breakfast
  • Zur Noll, 75€/night incl. breakfast
  • Haus im Sack, 95€/night incl. breakfast
  • Schwarzer Bär, Category I: 93,50€, Category II: 88,50€, incl. breakfast

The JAM2020 will take place at the Beutenberg Campus in Jena, Germany. Beutenberg Campus is a science and research site of national significance and with an excellent international reputation, situated in the south of Jena. The venue can be easily reached from the Jena city center using public transport.

We are planning the JAM to take place in three lecture halls which are connected via live streaming and the possibilities to interact, e.g. to ask questions. There will be several possibilities to interact and socialize with the speakers and other participants during the program and breaks, while respecting social distancing and hygiene measures: e.g. Coffee breaks will take place outside with open-air ventilation. Safety distance, hygiene and disinfection routines will be assured in all rooms, according to the guidelines of the local authorities.


JAM is organized by Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)

In Cooperation with: Aging Research Center (ARC) Jena | Jena Centre for Healthy Ageing | LRA Healthy Ageing