CF Technology Transfer Unit (SPARK@FLI)

Translating discoveries from bench to bedside is a challenging process and allows us do advance scientific discoveries and ensures that government-funded research translates into improved health for our society. The SPARK training program helps to understand clinical needs, develops a target product profile and strengthens project management abilities. These essential tools not only increase the likelihood of success, but also help decrease both the cost and time required to accomplish this goal (“de-risking”).

The Transfer Unit supports research labs to develop small molecules or biologicals or treatments of unmet clinical needs, respectively, with the aim to advance projects for any indication with high potential impact. To achieve this goal we utilize a variety of molecular and cell based techniques as well as different animal models.

The facility offers advisory, financial and personnel support, including:

  • Funds to asses and to de-risk your project
  • Funds to actually run a project
  • Implementation and execution of assays, e.g. toxicity assay, dose-response assay
  • Advice from SPARK advisory board, consisting of experts with translational experience
  • Mentored project management support
  • Help to establish defensible Intellectual Property
  • Training on what translation is all about
  • Education on drug and diagnostic development
  • Introduction to of the SPARK international network

We are currently using and offering support for the following assays and techniques:

Current Projects (2018/2019)

  • Targeting YAP in Breast Cancer
  • The Nucleolus: Biomarker and Target for healthy Aging

Previous Projects (2016-2018)

  • Innovative Nerve Sheath Tumor Therapy
  • Improving Myogenic activity of muscle stem cells
  • Targeting Proteotoxicity during Inflammation
  • Development of chemical inhibitors of p21-transcription for regenerative therapies
  • Pharmacological Antimutators for Diagnosis, Research and Therapy

3 further projects are currently carried out (2018/2019) or have been finalized (2016-2018), but cannot be disclosed here.

For further questions, please contact the CF manager Sonja Schätzlein.

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The 4th call for projects was placed with deadline of January 31st 2019.

The 5th call will be opened towards the end of 2019 (please contact Sonja Schätzlein for further information).

Most recent project update: July 10th 2019 (5-7 pm in SR "Golgi"):

  • Target Product Profile Presentation.

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SPARK Global Meeting: September 5-8, 2019 in Sydney, Australia

This program is based on the highly successful SPARK program developed at Stanford University (https://sparkmed.stanford.edu/). See also the SPARK INFO PACKAGE.

Topics covered during our educational seminars included

  • High Throughput screening in Academia
  • Technology transfer - How to deal with inventions and what Technology Transfer has to do with your day-to-day business (presentation, internal only)
  • Intellectual Property
  • How to build a Target Product Profile (presentation, internal only)
  • Introduction into Medicinal chemistry - How to assess and progress your initial screening hits (presentation, internal only)
  • Drug Discovery in Industry (presentation, internal only)
  • High Throughput screening in Academia
  • Pharmacokinetic/-dynamic/driven Drug Discovery
  • Reproducibility crisis, or: why most published research findings are false (presentation, internal only)
  • Organ on Chip (presentation, internal only)
  • Why can't I be Elon? Challenges of selling complex high-tech products to the world (presentation, internal only)
  • Patentability of Life Science Inventions: A comparison between European and US practice (presentation, internal only)
  • Transforming research to Business in the area of bioactive compounds: The case of nucleoside analogs (presentation, internal only)

We are always looking for speakers to cover the topics around Drug Development and Technology Transfer. Please contact Sonja Schätzlein for further information.

Internal users:
A free sample of the published book, “SPARK: A Practical Guide to Drug Development in Academia”, by Daria Mochly-Rosen and Kevin Grimes will be given to our SPARKees.

"SPARK Info Packet"

External users:
External guests are welcome to join our educational forum series (Wednesday 5-7PM in Golgi). Project presentations are only accessible with signed CDA.

Additional Links:

Team (incomplete due to Data protection)

Name Phone Email Position
Sonja Schätzlein +49 3641 656836 sonja.schaetzlein@leibniz-fli.de Core Facility Manager
Sylke Pfeifer +49 3641 656303 sylke.pfeifer@leibniz-fli.de Technical Assistant
Beate Szafranski +49 3641 656844 beate.szafranski@leibniz-fli.de Technical Assistant
Christoph Kaether +49 3641 656230 christoph.kaether@leibniz-fli.de Scientific Supervisor

* incomplete due to Data protection

For publications of individual CF members:  publications search 

Contact

Dr. Sonja Schätzlein

Sonja Schaetzlein
CF Manager
+49 3641 65-6836
sonja.schaetzlein@leibniz-fli.de

Christoph Kaether
Scientific Supervisor
christoph.kaether@leibniz-fli.de

Group Website

Overview CF Technology Transfer (SPARK)

Overview CF Technology Transfer
Overview CF Technology Transfer