Platzer Research Group

Genome Analysis:
The Blueprint of Life

The research group Genome Analysis with its group leader Matthias Platzer lays its focus on genetic and epigenetic aspects of aging. By means of state-of-the-art methods and tools, the information stored in DNA can be read out and the sequence of millions and millions of DNA building blocks may be determined within a short time. We use these methods to describe the genetic information as well as the processes underpinning e.g. the production of proteins and the alterations of these processes during aging.

We work on the functional and comparative analysis of genomes and transcriptomes of short- and long-lived model organisms in aging research. With clinical partners, we search for genetic and epigenetic variations determining the individual predisposition to healthy aging and complex aging-related diseases.

Offspring of two crossed genetic lines of N. furzeri strains.
N. furzeri Offspring

Contact

PD Dr. Matthias Platzer

Matthias Platzer
Group Leader
+49 3641 65-6240
matthias.platzer@leibniz-fli.de

Patricia Möckel
Secretary
+49 3641 65-6240
patricia.moeckel@leibniz-fli.de


Selected Publications

  • Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
    Reichwald* K, Petzold* A, Koch* P, Downie* BR, Hartmann* N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Görlach M, Than ME, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino** A, Englert** C, Platzer** M
    Cell 2015, 163(6), 1527-38 * equal contribution, ** co-senior authors, featured in
  • Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.
    Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte OW, Zarse K, Ristow M
    Nat Commun 2015, 6, 10043
  • The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels.
    Petzold A, Reichwald K, Groth M, Taudien S, Hartmann N, Priebe S, Shagin D, Englert C, Platzer M
    BMC Genomics 2013, 14, 185
  • Finishing the euchromatic sequence of the human genome.
    International Human Genome Sequencing Consortium (...), Platzer M, Baumgart C, Förste S, Galgoczy P, Glöckner G, Görlich Y, Heinze I, Jahn N, Lagemann D, Lehmann R, Meier E, Michaelis E, Petz U, Reichwald K, Schilhabel M, Seitz K, Siddiqui R, Taudien S, Wen G, Werler D, (...)
    Nature 2004, 431(7011), 931-45
  • Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.
    Hiller* M, Huse* K, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, Platzer M
    Nat Genet 2004, 36(12), 1255-7 * equal contribution