Platzer Research Group
The Blueprint of Life
The research group Genome Analysis with its group leader Matthias Platzer lays its focus on genetic and epigenetic aspects of aging. By means of state-of-the-art methods and tools, the information stored in DNA can be read out and the sequence of millions and millions of DNA building blocks may be determined within a short time. We use these methods to describe the genetic information as well as the processes underpinning e.g. the production of proteins and the alterations of these processes during aging.
We work on the functional and comparative analysis of genomes and transcriptomes of short- and long-lived model organisms in aging research. With clinical partners, we search for genetic and epigenetic variations determining the individual predisposition to healthy aging and complex aging-related diseases.
- Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.
Taudien* S, Lausser* L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler** HA, Platzer** M
EBioMedicine 2016, 12, 227-38 * equal contribution, ** co-senior authors
- Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
Reichwald* K, Petzold* A, Koch* P, Downie* BR, Hartmann* N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Görlach M, Than ME, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino** A, Englert** C, Platzer** M
Cell 2015, 163(6), 1527-38 * equal contribution, ** co-senior authors, featured in Cell Preview by Vanisha Lakhina and Coleen T. Murphy: Genome Sequencing Fishes out Longevity Genes. Cell. 2015 163(6):1312-3,Nature News by Ewen Callaway: Short-lived fish may hold clues to human age
- The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels.
Petzold A, Reichwald K, Groth M, Taudien S, Hartmann N, Priebe S, Shagin D, Englert C, Platzer M
BMC Genomics 2013, 14, 185
- Finishing the euchromatic sequence of the human genome.
International Human Genome Sequencing Consortium (...), Platzer M, Baumgart C, Förste S, Galgoczy P, Glöckner G, Görlich Y, Heinze I, Jahn N, Lagemann D, Lehmann R, Meier E, Michaelis E, Petz U, Reichwald K, Schilhabel M, Seitz K, Siddiqui R, Taudien S, Wen G, Werler D, (...)
Nature 2004, 431(7011), 931-45
- Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.
Hiller* M, Huse* K, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, Platzer M
Nat Genet 2004, 36(12), 1255-7 * equal contribution