Ori Research Group

Proteomics of Aging:
The Building Blocks of Our Body

At Alessandro Ori’s lab we are interested in studying how age, mutations and environmental factors affect our organs at the molecular level. We employ ultra-sensitive approaches that allow us to quantify thousands of proteins in tissues as well as in rare cell populations. Our goal is to identify in an unbiased way functionally relevant alterations of the proteome that will enable us to understand the mechanisms of organ deterioration that impact on healthy lifespan.

By studying the molecular changes that occur between young and old animals, we aim to understand what makes old organs more prone to failure and disease.
Aging protein modules


Dr. Alessandro Ori

Selected Publications

  • Spatiotemporal variation of mammalian protein complex stoichiometries.
    Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andrés-Pons A, Singer S, Bork P, Beck M
    Genome Biol 2016, 17(1), 47 featured in Research Highlights by Michael P. Washburn: There is no human interactome. Genome Biology 2016 17:48
  • Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
    Ori* A, Toyama* BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M
    Cell Syst 2015, 1(3), 224–237 * equal contribution, published during change of institution
  • Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs).
    Mackmull MT, Iskar M, Parca L, Singer S, Bork P, Ori** A, Beck** M
    Mol Cell Proteomics 2015, 14(5), 1350-60 ** co-corresponding authors
  • In situ structural analysis of the human nuclear pore complex.
    von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M
    Nature 2015, 526(7571), 140-3 published during change of institution
  • Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.
    Ori A, Banterle N, Iskar M, Andrés-Pons A, Escher C, Bui KH, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M
    Mol Syst Biol 2013, 9, 648